Is there association between vitamin D levels, apelin 36, and visfatin in PCOS?

Aim: We aimed to evaluate vitamin D, apelin-36, and visfatin levels in patients with polycystic ovary syndrome (PCOS). Material and method: The study was completed in six months, including a total of 110 patients who were admitted to the obstetrics and gynecology polyclinic. Patients with a diagnosi...

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Published in:Gynecological endocrinology 2016-05, Vol.32 (5), p.386-389
Main Authors: Kiyak Caglayan, Emel, Engin-Üstun, Yaprak, Sari, Nagihan, Göçmen, Ayşe Yesim, Seckin, Levent, Kara, Mustafa, Metin, Asli, Polat, M. Fevzi
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Language:English
Subjects:
Adipokines - blood
Adult
Apelin
Cytokines - blood
Female
Humans
Insulin resistance
Insulin Resistance - physiology
Intercellular Signaling Peptides and Proteins - blood
Lipids - blood
Nicotinamide Phosphoribosyltransferase - blood
ovary
polycystic ovary syndrome
Polycystic Ovary Syndrome - blood
Vitamin D - blood
Young Adult
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cited_by cdi_FETCH-LOGICAL-c366t-2cd779fc3b922746816e89c86649fc628120e468597699d39295bc47554207623
cites cdi_FETCH-LOGICAL-c366t-2cd779fc3b922746816e89c86649fc628120e468597699d39295bc47554207623
container_end_page 389
container_issue 5
container_start_page 386
container_title Gynecological endocrinology
container_volume 32
creator Kiyak Caglayan, Emel
Engin-Üstun, Yaprak
Sari, Nagihan
Göçmen, Ayşe Yesim
Seckin, Levent
Kara, Mustafa
Metin, Asli
Polat, M. Fevzi
description Aim: We aimed to evaluate vitamin D, apelin-36, and visfatin levels in patients with polycystic ovary syndrome (PCOS). Material and method: The study was completed in six months, including a total of 110 patients who were admitted to the obstetrics and gynecology polyclinic. Patients with a diagnosis of PCOS were divided into two subgroups according to their vitamin D levels. Thirty-four patients had 
doi_str_mv 10.3109/09513590.2015.1124260
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Fevzi</creator><creatorcontrib>Kiyak Caglayan, Emel ; Engin-Üstun, Yaprak ; Sari, Nagihan ; Göçmen, Ayşe Yesim ; Seckin, Levent ; Kara, Mustafa ; Metin, Asli ; Polat, M. Fevzi</creatorcontrib><description>Aim: We aimed to evaluate vitamin D, apelin-36, and visfatin levels in patients with polycystic ovary syndrome (PCOS). Material and method: The study was completed in six months, including a total of 110 patients who were admitted to the obstetrics and gynecology polyclinic. Patients with a diagnosis of PCOS were divided into two subgroups according to their vitamin D levels. Thirty-four patients had &lt;10 ng/ml of vitamin D deficiency and 21 patients had 10-30 ng/ml of vitamin D insufficiency, with each being defined as a subgroup. Results: Average apelin-36 and visfatin levels in PCOS patients were 2.52 ± 0.68 nmol/L and 72.63 ± 22:31 ng/ml, in the control group they were 0.92 ± 0.33 nmol/L, 24.66 ± 6 ng/ml, respectively. The difference found in PCOS patients was statistically significant (p = 0.0001, p = 0.0001). Conclusion: In conclusion, the present study shows that in PCOS patients with low levels of vitamin D, insulin resistance is greater and apelin-36 serum levels were significantly higher. Although there are different opinions in the literature on this subject, we believe that when vitamin D levels are brought to an optimal level in PCOS patient, it can prevent the negative effects of adipokines in the pathogenesis of PCOS.</description><identifier>ISSN: 0951-3590</identifier><identifier>EISSN: 1473-0766</identifier><identifier>DOI: 10.3109/09513590.2015.1124260</identifier><identifier>PMID: 26732135</identifier><language>eng</language><publisher>England: Taylor &amp; Francis</publisher><subject>Adipokines - blood ; Adult ; Apelin ; Cytokines - blood ; Female ; Humans ; Insulin resistance ; Insulin Resistance - physiology ; Intercellular Signaling Peptides and Proteins - blood ; Lipids - blood ; Nicotinamide Phosphoribosyltransferase - blood ; ovary ; polycystic ovary syndrome ; Polycystic Ovary Syndrome - blood ; Vitamin D - blood ; Young Adult</subject><ispartof>Gynecological endocrinology, 2016-05, Vol.32 (5), p.386-389</ispartof><rights>2015 Taylor &amp; Francis. 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-2cd779fc3b922746816e89c86649fc628120e468597699d39295bc47554207623</citedby><cites>FETCH-LOGICAL-c366t-2cd779fc3b922746816e89c86649fc628120e468597699d39295bc47554207623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26732135$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kiyak Caglayan, Emel</creatorcontrib><creatorcontrib>Engin-Üstun, Yaprak</creatorcontrib><creatorcontrib>Sari, Nagihan</creatorcontrib><creatorcontrib>Göçmen, Ayşe Yesim</creatorcontrib><creatorcontrib>Seckin, Levent</creatorcontrib><creatorcontrib>Kara, Mustafa</creatorcontrib><creatorcontrib>Metin, Asli</creatorcontrib><creatorcontrib>Polat, M. Fevzi</creatorcontrib><title>Is there association between vitamin D levels, apelin 36, and visfatin in PCOS?</title><title>Gynecological endocrinology</title><addtitle>Gynecol Endocrinol</addtitle><description>Aim: We aimed to evaluate vitamin D, apelin-36, and visfatin levels in patients with polycystic ovary syndrome (PCOS). Material and method: The study was completed in six months, including a total of 110 patients who were admitted to the obstetrics and gynecology polyclinic. Patients with a diagnosis of PCOS were divided into two subgroups according to their vitamin D levels. Thirty-four patients had &lt;10 ng/ml of vitamin D deficiency and 21 patients had 10-30 ng/ml of vitamin D insufficiency, with each being defined as a subgroup. Results: Average apelin-36 and visfatin levels in PCOS patients were 2.52 ± 0.68 nmol/L and 72.63 ± 22:31 ng/ml, in the control group they were 0.92 ± 0.33 nmol/L, 24.66 ± 6 ng/ml, respectively. The difference found in PCOS patients was statistically significant (p = 0.0001, p = 0.0001). Conclusion: In conclusion, the present study shows that in PCOS patients with low levels of vitamin D, insulin resistance is greater and apelin-36 serum levels were significantly higher. Although there are different opinions in the literature on this subject, we believe that when vitamin D levels are brought to an optimal level in PCOS patient, it can prevent the negative effects of adipokines in the pathogenesis of PCOS.</description><subject>Adipokines - blood</subject><subject>Adult</subject><subject>Apelin</subject><subject>Cytokines - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - physiology</subject><subject>Intercellular Signaling Peptides and Proteins - blood</subject><subject>Lipids - blood</subject><subject>Nicotinamide Phosphoribosyltransferase - blood</subject><subject>ovary</subject><subject>polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - blood</subject><subject>Vitamin D - blood</subject><subject>Young Adult</subject><issn>0951-3590</issn><issn>1473-0766</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp9kN1LwzAUxYMobk7_BCWPPtiZjzZpnlTm12AwQX0OWXqLlbSdSbex_96UbT4KF3I5_M655CB0ScmYU6JuicoozxQZM0KzMaUsZYIcoSFNJU-IFOIYDXsm6aEBOgvhmxDKU8lO0YAJyVm0D9F8GnD3BR6wCaG1lemqtsEL6DYADV5XnamrBj9iB2tw4QabJbgocBHXpohAKKOlwXHeJvP3u3N0UhoX4GL_jtDn89PH5DWZzV-mk4dZYrkQXcJsIaUqLV8oxmQqciogVzYXIo2qYDllBKKcKSmUKrhiKlvYVGZZyuLnGB-h613u0rc_KwidrqtgwTnTQLsKmsb4POeC9Gi2Q61vQ_BQ6qWvauO3mhLdd6kPXeq-S73vMvqu9idWixqKP9ehvAjc74CqKVtfm03rXaE7s3WtL71pbBX6_P9u_AIveH8u</recordid><startdate>20160503</startdate><enddate>20160503</enddate><creator>Kiyak Caglayan, Emel</creator><creator>Engin-Üstun, Yaprak</creator><creator>Sari, Nagihan</creator><creator>Göçmen, Ayşe Yesim</creator><creator>Seckin, Levent</creator><creator>Kara, Mustafa</creator><creator>Metin, Asli</creator><creator>Polat, M. 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Fevzi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is there association between vitamin D levels, apelin 36, and visfatin in PCOS?</atitle><jtitle>Gynecological endocrinology</jtitle><addtitle>Gynecol Endocrinol</addtitle><date>2016-05-03</date><risdate>2016</risdate><volume>32</volume><issue>5</issue><spage>386</spage><epage>389</epage><pages>386-389</pages><issn>0951-3590</issn><eissn>1473-0766</eissn><abstract>Aim: We aimed to evaluate vitamin D, apelin-36, and visfatin levels in patients with polycystic ovary syndrome (PCOS). Material and method: The study was completed in six months, including a total of 110 patients who were admitted to the obstetrics and gynecology polyclinic. Patients with a diagnosis of PCOS were divided into two subgroups according to their vitamin D levels. Thirty-four patients had &lt;10 ng/ml of vitamin D deficiency and 21 patients had 10-30 ng/ml of vitamin D insufficiency, with each being defined as a subgroup. 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source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)
subjects Adipokines - blood
Adult
Apelin
Cytokines - blood
Female
Humans
Insulin resistance
Insulin Resistance - physiology
Intercellular Signaling Peptides and Proteins - blood
Lipids - blood
Nicotinamide Phosphoribosyltransferase - blood
ovary
polycystic ovary syndrome
Polycystic Ovary Syndrome - blood
Vitamin D - blood
Young Adult
title Is there association between vitamin D levels, apelin 36, and visfatin in PCOS?
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