Efficacy of the apitherapy in the treatment of recalcitrant localized plaque psoriasis and evaluation of tumor necrosis factor-alpha (TNF-α) serum level: A double-blind randomized clinical trial

Background: No universal consensus about optimal modality for treating the recalcitrant localized plaque psoriasis (RLPP) is available. Objective: To evaluate the immunological and clinical therapeutic effect of using apitherapy in the treatment of RLPP. Methods: Randomized 50 patients with RLPP rec...

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Bibliographic Details
Published in:The Journal of dermatological treatment 2015-07, Vol.26 (4), p.335-339
Main Authors: Eltaher, Soha, Mohammed, Ghada F., Younes, Soha, Elakhras, Atef
Format: Article
Language:English
Subjects:
Adult
Apitherapy
Apitherapy - methods
bee venom
Double-Blind Method
Female
Humans
Male
PGA
Psoriasis - therapy
recalcitrant localized plaque psoriasis
Remission Induction
TNF-α
Tumor Necrosis Factor-alpha - blood
Young Adult
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Summary:Background: No universal consensus about optimal modality for treating the recalcitrant localized plaque psoriasis (RLPP) is available. Objective: To evaluate the immunological and clinical therapeutic effect of using apitherapy in the treatment of RLPP. Methods: Randomized 50 patients with RLPP received apitherapy (n = 25) and placebo (n = 25) every week. Both treatments were injected into lesions at weekly intervals for a maximum of 12 treatments. Following up was 6 months later. Tumor necrosis factor-alpha (TNF-α) level was measured at pre-study and at 12th week. Results: A significant difference was found between the therapeutic responses of RLPP to the apitherapy and placebo groups (p
ISSN:0954-6634
1471-1753
DOI:10.3109/09546634.2014.990411