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Efficacy of the apitherapy in the treatment of recalcitrant localized plaque psoriasis and evaluation of tumor necrosis factor-alpha (TNF-α) serum level: A double-blind randomized clinical trial
Background: No universal consensus about optimal modality for treating the recalcitrant localized plaque psoriasis (RLPP) is available. Objective: To evaluate the immunological and clinical therapeutic effect of using apitherapy in the treatment of RLPP. Methods: Randomized 50 patients with RLPP rec...
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| Published in: | The Journal of dermatological treatment 2015-07, Vol.26 (4), p.335-339 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c278t-9405b1d2a93c023c0e6ce8c40dcd0a590738e3d3c232c87bd8403a4390c7b4893 |
| container_end_page | 339 |
| container_issue | 4 |
| container_start_page | 335 |
| container_title | The Journal of dermatological treatment |
| container_volume | 26 |
| creator | Eltaher, Soha Mohammed, Ghada F. Younes, Soha Elakhras, Atef |
| description | Background: No universal consensus about optimal modality for treating the recalcitrant localized plaque psoriasis (RLPP) is available.
Objective: To evaluate the immunological and clinical therapeutic effect of using apitherapy in the treatment of RLPP.
Methods: Randomized 50 patients with RLPP received apitherapy (n = 25) and placebo (n = 25) every week. Both treatments were injected into lesions at weekly intervals for a maximum of 12 treatments. Following up was 6 months later. Tumor necrosis factor-alpha (TNF-α) level was measured at pre-study and at 12th week.
Results: A significant difference was found between the therapeutic responses of RLPP to the apitherapy and placebo groups (p |
| doi_str_mv | 10.3109/09546634.2014.990411 |
| format | article |
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Objective: To evaluate the immunological and clinical therapeutic effect of using apitherapy in the treatment of RLPP.
Methods: Randomized 50 patients with RLPP received apitherapy (n = 25) and placebo (n = 25) every week. Both treatments were injected into lesions at weekly intervals for a maximum of 12 treatments. Following up was 6 months later. Tumor necrosis factor-alpha (TNF-α) level was measured at pre-study and at 12th week.
Results: A significant difference was found between the therapeutic responses of RLPP to the apitherapy and placebo groups (p<0.001). In the apitherapy group, complete response was achieved in 92% of patients. There was statistically significant decrease in TNF-α in the apitherapy group compared to the placebo group. No recurrence was observed in the apitherapy group.
Conclusion: Apitherapy is effective and a safe treatment for recalcitrant localized plaque psoriasis, when other topical or physical therapies have failed.</description><identifier>ISSN: 0954-6634</identifier><identifier>EISSN: 1471-1753</identifier><identifier>DOI: 10.3109/09546634.2014.990411</identifier><identifier>PMID: 25424047</identifier><language>eng</language><publisher>England: Informa Healthcare</publisher><subject>Adult ; Apitherapy ; Apitherapy - methods ; bee venom ; Double-Blind Method ; Female ; Humans ; Male ; PGA ; Psoriasis - therapy ; recalcitrant localized plaque psoriasis ; Remission Induction ; TNF-α ; Tumor Necrosis Factor-alpha - blood ; Young Adult</subject><ispartof>The Journal of dermatological treatment, 2015-07, Vol.26 (4), p.335-339</ispartof><rights>2014 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c278t-9405b1d2a93c023c0e6ce8c40dcd0a590738e3d3c232c87bd8403a4390c7b4893</citedby><cites>FETCH-LOGICAL-c278t-9405b1d2a93c023c0e6ce8c40dcd0a590738e3d3c232c87bd8403a4390c7b4893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25424047$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eltaher, Soha</creatorcontrib><creatorcontrib>Mohammed, Ghada F.</creatorcontrib><creatorcontrib>Younes, Soha</creatorcontrib><creatorcontrib>Elakhras, Atef</creatorcontrib><title>Efficacy of the apitherapy in the treatment of recalcitrant localized plaque psoriasis and evaluation of tumor necrosis factor-alpha (TNF-α) serum level: A double-blind randomized clinical trial</title><title>The Journal of dermatological treatment</title><addtitle>J Dermatolog Treat</addtitle><description>Background: No universal consensus about optimal modality for treating the recalcitrant localized plaque psoriasis (RLPP) is available.
Objective: To evaluate the immunological and clinical therapeutic effect of using apitherapy in the treatment of RLPP.
Methods: Randomized 50 patients with RLPP received apitherapy (n = 25) and placebo (n = 25) every week. Both treatments were injected into lesions at weekly intervals for a maximum of 12 treatments. Following up was 6 months later. Tumor necrosis factor-alpha (TNF-α) level was measured at pre-study and at 12th week.
Results: A significant difference was found between the therapeutic responses of RLPP to the apitherapy and placebo groups (p<0.001). In the apitherapy group, complete response was achieved in 92% of patients. There was statistically significant decrease in TNF-α in the apitherapy group compared to the placebo group. No recurrence was observed in the apitherapy group.
Conclusion: Apitherapy is effective and a safe treatment for recalcitrant localized plaque psoriasis, when other topical or physical therapies have failed.</description><subject>Adult</subject><subject>Apitherapy</subject><subject>Apitherapy - methods</subject><subject>bee venom</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>PGA</subject><subject>Psoriasis - therapy</subject><subject>recalcitrant localized plaque psoriasis</subject><subject>Remission Induction</subject><subject>TNF-α</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Young Adult</subject><issn>0954-6634</issn><issn>1471-1753</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp9kcFu1DAQhi0EokvhDRDysRyyjGNnk3BBVdUCUgWXco4m9kQ1cuJgO62Wt-IZuPNMOLstRw7WaEbfzD_jn7HXArZSQPsO2krtdlJtSxBq27aghHjCNkLVohB1JZ-yzYoUK3PCXsT4HUDIHTTP2UlZqVKBqjfs9-UwWI16z_3A0y1xnG0OAec9t9OhkgJhGmlKKxJIo9M2Bcy58zmxP8nw2eGPhfgcfbAYbeQ4GU536BZM1k-H4cvoA59IB78CA-rkQ4FuvkV-dvPlqvjz6y2PFJaRO7oj956fc-OX3lHRO5vHZUnjx4OczoW8tcu7WXQv2bMBXaRXD_GUfbu6vLn4VFx__fj54vy60GXdpKJVUPXClNhKDWV-tNPUaAVGG8CqhVo2JI3UpSx1U_emUSBRyRZ03aumlafs7Dh3Dj5fG1M32qjJOZzIL7ETNZS7SoKSGVVHdL02Bhq6OdgRw74T0K32dY_2dat93dG-3PbmQWHpRzL_mh79ysCHI2CnwYcR731wpku4dz4M-YO0jev4_0j8BdQ1rY0</recordid><startdate>20150704</startdate><enddate>20150704</enddate><creator>Eltaher, Soha</creator><creator>Mohammed, Ghada F.</creator><creator>Younes, Soha</creator><creator>Elakhras, Atef</creator><general>Informa Healthcare</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150704</creationdate><title>Efficacy of the apitherapy in the treatment of recalcitrant localized plaque psoriasis and evaluation of tumor necrosis factor-alpha (TNF-α) serum level: A double-blind randomized clinical trial</title><author>Eltaher, Soha ; Mohammed, Ghada F. ; Younes, Soha ; Elakhras, Atef</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c278t-9405b1d2a93c023c0e6ce8c40dcd0a590738e3d3c232c87bd8403a4390c7b4893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Apitherapy</topic><topic>Apitherapy - methods</topic><topic>bee venom</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>PGA</topic><topic>Psoriasis - therapy</topic><topic>recalcitrant localized plaque psoriasis</topic><topic>Remission Induction</topic><topic>TNF-α</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eltaher, Soha</creatorcontrib><creatorcontrib>Mohammed, Ghada F.</creatorcontrib><creatorcontrib>Younes, Soha</creatorcontrib><creatorcontrib>Elakhras, Atef</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of dermatological treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eltaher, Soha</au><au>Mohammed, Ghada F.</au><au>Younes, Soha</au><au>Elakhras, Atef</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of the apitherapy in the treatment of recalcitrant localized plaque psoriasis and evaluation of tumor necrosis factor-alpha (TNF-α) serum level: A double-blind randomized clinical trial</atitle><jtitle>The Journal of dermatological treatment</jtitle><addtitle>J Dermatolog Treat</addtitle><date>2015-07-04</date><risdate>2015</risdate><volume>26</volume><issue>4</issue><spage>335</spage><epage>339</epage><pages>335-339</pages><issn>0954-6634</issn><eissn>1471-1753</eissn><abstract>Background: No universal consensus about optimal modality for treating the recalcitrant localized plaque psoriasis (RLPP) is available.
Objective: To evaluate the immunological and clinical therapeutic effect of using apitherapy in the treatment of RLPP.
Methods: Randomized 50 patients with RLPP received apitherapy (n = 25) and placebo (n = 25) every week. Both treatments were injected into lesions at weekly intervals for a maximum of 12 treatments. Following up was 6 months later. Tumor necrosis factor-alpha (TNF-α) level was measured at pre-study and at 12th week.
Results: A significant difference was found between the therapeutic responses of RLPP to the apitherapy and placebo groups (p<0.001). In the apitherapy group, complete response was achieved in 92% of patients. There was statistically significant decrease in TNF-α in the apitherapy group compared to the placebo group. No recurrence was observed in the apitherapy group.
Conclusion: Apitherapy is effective and a safe treatment for recalcitrant localized plaque psoriasis, when other topical or physical therapies have failed.</abstract><cop>England</cop><pub>Informa Healthcare</pub><pmid>25424047</pmid><doi>10.3109/09546634.2014.990411</doi><tpages>5</tpages></addata></record> |
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| ispartof | The Journal of dermatological treatment, 2015-07, Vol.26 (4), p.335-339 |
| issn | 0954-6634 1471-1753 |
| language | eng |
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| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Adult Apitherapy Apitherapy - methods bee venom Double-Blind Method Female Humans Male PGA Psoriasis - therapy recalcitrant localized plaque psoriasis Remission Induction TNF-α Tumor Necrosis Factor-alpha - blood Young Adult |
| title | Efficacy of the apitherapy in the treatment of recalcitrant localized plaque psoriasis and evaluation of tumor necrosis factor-alpha (TNF-α) serum level: A double-blind randomized clinical trial |
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