Coconut kernel-derived proteins enhance hypolipidemic and antioxidant activity in alloxan-induced diabetic rats

Impaired lipid levels and oxidative stress are indicative of malfunction of endogenous antioxidant capacity. The aim of this study was to determine the effect of coconut kernel protein (CKP) on the lipid peroxides and antioxidant enzyme activities in diabetic rats. Diabetes was induced prior to feed...

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Bibliographic Details
Published in:International journal of food sciences and nutrition 2013-05, Vol.64 (3), p.327-332
Main Authors: Salil, Gopalakrishnan, Nevin, Kottayath Govindan, Rajamohan, Thankappan
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Antioxidants - metabolism
Antioxidants - pharmacology
Antioxidants - therapeutic use
Arginine - pharmacology
Arginine - therapeutic use
coconut kernel protein
Cocos - chemistry
Diabetes
Diabetes Mellitus, Experimental - complications
Diabetes Mellitus, Experimental - drug therapy
Diabetes Mellitus, Experimental - metabolism
Dietary Proteins - pharmacology
Dietary Proteins - therapeutic use
Enzyme kinetics
Food science
Hypolipidemic Agents - pharmacology
Hypolipidemic Agents - therapeutic use
Lipids
Lipids - blood
Male
Oxidative stress
Oxidative Stress - drug effects
peroxidation
Peroxides - metabolism
Plant Proteins - chemistry
Plant Proteins - pharmacology
Plant Proteins - therapeutic use
Rats
Rats, Sprague-Dawley
Rodents
Seeds - chemistry
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Summary:Impaired lipid levels and oxidative stress are indicative of malfunction of endogenous antioxidant capacity. The aim of this study was to determine the effect of coconut kernel protein (CKP) on the lipid peroxides and antioxidant enzyme activities in diabetic rats. Diabetes was induced prior to feeding by injecting a single dose of alloxan (150 mg/kg body weight) intraperitoneally. CKP (8% w/w) was administered to these rats along with a semi-synthetic diet for 45 days. After the experimental period, peroxide products and antioxidant enzyme activities were determined. Results show that CKP maintained the antioxidant enzyme activities and levels of peroxides to the normal levels in treated group compared to diabetic rats. This study clearly show that CKP has potential effect in lowering oxidative stress associated with diabetes. This beneficial effect of CKP may be due to the high amount of biologically potent arginine present in it.
ISSN:0963-7486
1465-3478
DOI:10.3109/09637486.2012.738646