Synthesis of 2-deoxygalactopyranoside derivatives of benzyl alcohols with β-galactosidase from Aspergillus oryzae

Abstract The stereoselective synthesis of 2-deoxyglycosides is a challenge. Glycosidases are capable of catalyzing the synthesis of glycosidic linkages by the absolute stereoselectivity of the anomeric center. We report on an efficient stereoselective synthesis of benzyl β-D-2-deoxygalactopyranoside...

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Bibliographic Details
Published in:Biocatalysis and biotransformation 2014-12, Vol.32 (5-6), p.290-294
Main Authors: Hahn, Przemys aw, Kasprzycka, Anna, Szeja, Wies aw
Format: Article
Language:English
Subjects:
2-deoxygalactosyl derivatives
Aspergillus oryzae
enzymatic synthesis
β-galactosidase
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Summary:Abstract The stereoselective synthesis of 2-deoxyglycosides is a challenge. Glycosidases are capable of catalyzing the synthesis of glycosidic linkages by the absolute stereoselectivity of the anomeric center. We report on an efficient stereoselective synthesis of benzyl β-D-2-deoxygalactopyranosides in the reaction of galactal with alcohols catalyzed using β-galactosidase from Aspergillus oryzae.
ISSN:1024-2422
1029-2446
DOI:10.3109/10242422.2014.975216