Current status and perspectives on protein-based pneumococcal vaccines

Abstract Despite the efforts to expand the availability of conjugate vaccines, pneumococcal diseases still pose an enormous burden worldwide. Therefore, several proteins have been investigated as alternative vaccines, alone or in combination with other antigens. With an increasing array of technique...

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Bibliographic Details
Published in:Critical reviews in microbiology 2015-06, Vol.41 (2), p.190-200
Main Authors: Darrieux, Michelle, Goulart, Cibelly, Briles, David, Leite, Luciana Cezar de Cerqueira
Format: Article
Language:English
Subjects:
Antigens, Bacterial - genetics
Antigens, Bacterial - immunology
Bacterial Proteins - genetics
Bacterial Proteins - immunology
Drug Discovery - trends
Humans
Pneumococcal Infections - epidemiology
Pneumococcal Infections - prevention & control
Pneumococcal proteins
Pneumococcal Vaccines - genetics
Pneumococcal Vaccines - immunology
Pneumococcal Vaccines - isolation & purification
Streptococcus pneumoniae
Streptococcus pneumoniae - genetics
Streptococcus pneumoniae - immunology
vaccine
Vaccines, Synthetic - genetics
Vaccines, Synthetic - immunology
Vaccines, Synthetic - isolation & purification
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Summary:Abstract Despite the efforts to expand the availability of conjugate vaccines, pneumococcal diseases still pose an enormous burden worldwide. Therefore, several proteins have been investigated as alternative vaccines, alone or in combination with other antigens. With an increasing array of techniques, many of which arose from the publication of the bacterial genome, several proteins have been identified as potential vaccine candidates, and some have even progressed to clinical trials. Also, whole cell vaccines are being studied for the induction of broad ranging protective responses. Here, we briefly summarize the current knowledge on pneumococcal proteins that are being investigated as potential vaccine candidates against pneumococcal infections, and provide an insight on the future generation of protein-based vaccines against Streptococcus pneumoniae.
ISSN:1040-841X
1549-7828
DOI:10.3109/1040841X.2013.813902