The Immunoproteasome in oxidative stress, aging, and disease

The Immunoproteasome has traditionally been viewed primarily for its role in peptide production for antigen presentation by the major histocompatibility complex, which is critical for immunity. However, recent research has shown that the Immunoproteasome is also very important for the clearance of o...

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Bibliographic Details
Published in:Critical reviews in biochemistry and molecular biology 2016-07, Vol.51 (4), p.268-281
Main Authors: Johnston-Carey, Helen K., Pomatto, Laura C. D., Davies, Kelvin J. A.
Format: Article
Language:English
Subjects:
20S core
Adaptation
Aging
Animals
Humans
IFN-γ
Immune System
Interferon-gamma
IκBα
Nrf2
Oxidative Stress
Proteasome Endopeptidase Complex - metabolism
Proteasome Endopeptidase Complex - physiology
Protein Aggregation, Pathological
proteostasis
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Summary:The Immunoproteasome has traditionally been viewed primarily for its role in peptide production for antigen presentation by the major histocompatibility complex, which is critical for immunity. However, recent research has shown that the Immunoproteasome is also very important for the clearance of oxidatively damaged proteins in homeostasis, and especially during stress and disease. The importance of the Immunoproteasome in protein degradation has become more evident as diseases characterized by protein aggregates have also been linked to deficiencies of the Immunoproteasome. Additionally, there are now diseases defined by mutations or polymorphisms within Immunoproteasome-specific subunit genes, further suggesting its crucial role in cytokine signaling and protein homeostasis (or "proteostasis"). The purpose of this review is to highlight our growing understanding of the importance of the Immunoproteasome in the management of protein quality control, and the detrimental impact of its dysregulation during disease and aging.
ISSN:1040-9238
1549-7798
DOI:10.3109/10409238.2016.1172554