Obesity reduces methionine sulphoxide reductase activity in visceral adipose tissue

Abstract Visceral obesity is linked to insulin resistance and cardiovascular disease. A recent genetic study indicated that the gene locus for the anti-oxidant defense enzyme methionine sulphoxide reductase A (MsrA) is positively associated with the development of visceral adiposity. This work teste...

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Bibliographic Details
Published in:Free radical research 2011-09, Vol.45 (9), p.1052-1060
Main Authors: Uthus, Eric O., Picklo, Matthew J.
Format: Article
Language:English
Subjects:
adipose
Animals
Intra-Abdominal Fat - enzymology
Liver - enzymology
Male
Obesity - enzymology
oxidative damage
Oxidative Stress
Oxidoreductases - metabolism
Rats
Rats, Zucker
Subcutaneous Fat - enzymology
visceral
Zucker
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Summary:Abstract Visceral obesity is linked to insulin resistance and cardiovascular disease. A recent genetic study indicated that the gene locus for the anti-oxidant defense enzyme methionine sulphoxide reductase A (MsrA) is positively associated with the development of visceral adiposity. This work tested the hypothesis that Msr activity is diminished in visceral fat as a result of obesity. It used two animal models of obesity, wild-type rats fed a high-fat (45% of calories from fat) diet and Zucker rats fed a 10% fat calorie diet. The data indicate that MsrA activity was selectively reduced by ∼ 25% in the visceral adipose, but not subcutaneous adipose or liver, of both rat models as compared to control, wild type rats receiving a 10% fat calorie diet. MsrB activity was similarly reduced only in visceral fat. The data indicate that Msr activity is reduced by obesity and may alter oxidative stress signalling of obesity.
ISSN:1071-5762
1029-2470
DOI:10.3109/10715762.2011.591793