Mechanism of the anti-hypertensive property of the naturally occurring phenolic, malabaricone C in DOCA-salt rats

In this study, we studied whether chronic oral administration of the natural antioxidant, malabaricone C (mal C) can reduce blood pressure (BP) and attenuate cardio-vascular remodeling in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. The dose of mal C for its anti-hypertensive action wa...

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Bibliographic Details
Published in:Free radical research 2016-01, Vol.50 (1), p.111-121
Main Authors: Rathee, Jitesh S., Patro, Birija S., Brown, Lindsay, Chattopadhyay, Subrata
Format: Article
Language:English
Subjects:
Animals
Antihypertensive Agents - therapeutic use
Antioxidants - pharmacology
Aorta - drug effects
Aorta - pathology
Cardiac remodeling
Desoxycorticosterone Acetate
Disease Models, Animal
fibrosis
Heart - drug effects
hypertension
Hypertension - chemically induced
Hypertension - drug therapy
hypertrophy
Hypertrophy - drug therapy
malabaricone C
Male
Myocardium - pathology
oxidative stress
Oxidative Stress - drug effects
Rats
Resorcinols - therapeutic use
Vasodilation - drug effects
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Summary:In this study, we studied whether chronic oral administration of the natural antioxidant, malabaricone C (mal C) can reduce blood pressure (BP) and attenuate cardio-vascular remodeling in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. The dose of mal C for its anti-hypertensive action was optimized by measuring the systolic BP (SBP). DOCA-salt rats showed very high SBP, associated with organ hypertrophy, collagen depositions, and inflammatory infiltrations in cardiac and aortic sections, reduced plasma total antioxidant status and NO level, and increased levels of TBARS, PGI2 as well as vasoconstrictors (AVP, Big ET, and ET-1). DOCA-salt also reduced smooth muscle- and endothelium-dependent vascular relaxation in rats. Mal C reversed all these changes of the DOCA-salt rats and improved their vascular reactivity. Mal C exerts anti-hypertensive property in DOCA-salt rats by reducing oxidative stress and organ hypertrophy, and improving endothelial and vascular functions. Given that mal C has appreciable natural abundance and is non-toxic to rodents, further studies would help in establishing its medicinal potential against hypertension.
ISSN:1071-5762
1029-2470
DOI:10.3109/10715762.2015.1112005