Preparation, characterization and dissolution studies of fast release diclofenac sodium tablets from PVP solid dispersions

Diclofenac sodium is a non-steroidal anti-inflammatory drug widely used in the treatment of ankylosing spondylitis, rheumatoid arthritis and osteoarthritis. In this context, a rapid onset of action is required. Thus, the aim of this study was to formulate diclofenac sodium-PVP K-30 fast release tabl...

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Bibliographic Details
Published in:Pharmaceutical development and technology 2010-04, Vol.15 (2), p.162-168
Main Authors: Lamas, Maria C., Leonardi, Darío, Lambri, Osvaldo A., Bassani, Georgina, Barrera, María G., Bolmaro, Raúl E., Salomon, Claudio J.
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Biological and medical sciences
Diclofenac - administration & dosage
Diclofenac - chemistry
diclofenac sodium
dissolution
Drug Carriers - chemistry
Drug Stability
Drug Storage
General pharmacology
kneading
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Povidone - chemistry
PVP K-30
Solid dispersions
Solubility
Tablets
Time Factors
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Summary:Diclofenac sodium is a non-steroidal anti-inflammatory drug widely used in the treatment of ankylosing spondylitis, rheumatoid arthritis and osteoarthritis. In this context, a rapid onset of action is required. Thus, the aim of this study was to formulate diclofenac sodium-PVP K-30 fast release tablets from solid dispersions. The physical state and drug:carrier interactions were analyzed by X-ray diffraction and scanning electron microscopy and stability upon storage was also studied. Dissolution rate of diclofenac sodium from solid dispersions was markedly enhanced by increasing the polymer concentration.
ISSN:1083-7450
1097-9867
DOI:10.3109/10837450903085400