Systemic amyloidosis in a cheetah (Acinonyx jubatus)

A captive, 9 year old female cheetah (Acinonyxjubatus) with progressive signs of chronic renal failure was euthanized Histologic studies of the kidney revealed severe glomerular and medullary amyloidosis. The amyloid stained positivelv with Congo red and showed green birefringence under polarized li...

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Bibliographic Details
Published in:Amyloid 1997, Vol.4 (2), p.98-103
Main Authors: Ofri, Ron, Nyska, Abraham, Linke, Reinhold P., Shtrasburg, Shmuel, Livneh, Avi, Gal, Rivka
Format: Article
Language:English
Subjects:
AA arnyloid
Cheetah
chronic renal failure
feline
kidney
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Summary:A captive, 9 year old female cheetah (Acinonyxjubatus) with progressive signs of chronic renal failure was euthanized Histologic studies of the kidney revealed severe glomerular and medullary amyloidosis. The amyloid stained positivelv with Congo red and showed green birefringence under polarized light. Based on potassium permanganate sensitivity and the immunohistochemical reaction with monoclonal antibodies, the renal amyloid was classlfied as AA. Amyloid was also deposited in the liver and heart. Elec-trophoresis of heart and kidney tissue showed two protein bands reflecting serum amyloid A. This is the first detailed report of amyloidosis leading to renal failure in a highly endangered species.
ISSN:1350-6129
1744-2818
DOI:10.3109/13506129708995277