Polymorphisms in transcobalamin II gene is associated with coronary artery disease in Indian population

Transcobalamin (TCII) is a key enzyme involved in intracellular transport of vitamin B12. We had earlier shown that vitamin B12 levels are associated with Coronary Artery Disease (CAD). Herein, we evaluated the association of four nonsynonymous single nucleotide polymorphisms (SNPs) of TCII gene wit...

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Bibliographic Details
Published in:Biomarkers 2012-03, Vol.17 (2), p.119-124
Main Authors: Garg, Gaurav, Kumar, Jitender, Tanwar, Vinay Singh, Basak, Trayambak, Seth, Sandeep, Karthikeyan, Ganesan, Sengupta, Shantanu
Format: Article
Language:English
Subjects:
Adult
Alleles
Case-Control Studies
Coronary artery disease
Coronary Artery Disease - blood
Coronary Artery Disease - genetics
European Continental Ancestry Group - genetics
Female
Gene Frequency
Genotype
Humans
India
Male
Middle Aged
Polymorphism, Single Nucleotide - genetics
Regression Analysis
single nucleotide polymorphism
transcobalamin
Transcobalamins - genetics
Transcobalamins - metabolism
vitamin B
Vitamin B 12 - blood
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Summary:Transcobalamin (TCII) is a key enzyme involved in intracellular transport of vitamin B12. We had earlier shown that vitamin B12 levels are associated with Coronary Artery Disease (CAD). Herein, we evaluated the association of four nonsynonymous single nucleotide polymorphisms (SNPs) of TCII gene with CAD in 1398 individuals (589 CAD cases and 809 controls). Using logistic regression, we found that three SNPs (G1196A, C776G and C1043T) were significantly associated with CAD and one (G1196A) with vitamin B12 levels even after controlling for confounding factors. Thus, polymorphisms in TCII gene may play an important role in the etiology of CAD.
ISSN:1354-750X
1366-5804
DOI:10.3109/1354750X.2011.642408