Neuroglobin and Nogo-a as biomarkers for the severity and prognosis of traumatic brain injury

Objective: To identify the early changes of serum neuroglobin and Nogo-A concentrations and the relations to traumatic brain injury (TBI) severity and prognosis. Methods: Serum samples were obtained and analyzed from 34 patients with TBI within the first 96 h after injury. Comparative analysis combi...

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Bibliographic Details
Published in:Biomarkers 2015-10, Vol.20 (6-7), p.495-501
Main Authors: Chen, Hao, Cao, He-Li, Chen, Shi-Wen, Guo, Yan, Gao, Wen-Wei, Tian, Heng-Li, Xue, Li-Xia
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarker
Biomarkers - blood
Brain Injuries - blood
Brain Injuries - diagnosis
Female
Glasgow Coma Scale
Globins
Humans
Male
Middle Aged
Myelin Proteins - blood
Nerve Tissue Proteins - blood
neuroglobin
Nogo Proteins
Nogo-A
Prognosis
Prospective Studies
ROC Curve
Time Factors
traumatic brain injury
Young Adult
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Summary:Objective: To identify the early changes of serum neuroglobin and Nogo-A concentrations and the relations to traumatic brain injury (TBI) severity and prognosis. Methods: Serum samples were obtained and analyzed from 34 patients with TBI within the first 96 h after injury. Comparative analysis combined with Glasgow Coma Scale (GCS) scores and the 6-month prognosis of these patients was performed. Results: Significant correlations were found between peak serum neuroglobin and Nogo-A concentrations and a patient's GCS score on admission (p 
ISSN:1354-750X
1366-5804
DOI:10.3109/1354750X.2015.1094138