NMR- and GC/MS-based metabolomics of sulfur mustard exposed individuals: a pilot study

Sulfur mustard (SM) is a potent alkylating agent and its effects on cells and tissues are varied and complex. Due to limitations in the diagnostics of sulfur mustard exposed individuals (SMEIs) by noninvasive approaches, there is a great necessity to develop novel techniques and biomarkers for this...

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Bibliographic Details
Published in:Biomarkers 2016-08, Vol.21 (6), p.479-489
Main Authors: Nobakht, B. Fatemeh, Aliannejad, Rasoul, Rezaei-Tavirani, Mostafa, Arefi Oskouie, Afsaneh, Naseri, Mohammad Taghi, Parastar, Hadi, Aliakbarzadeh, Ghazaleh, Fathi, Fariba, Taheri, Salman
Format: Article
Language:English
Subjects:
Adult
Amino Acids - blood
Biomarkers - blood
Case-Control Studies
Chemical Warfare Agents - toxicity
Environmental Exposure
Gas Chromatography-Mass Spectrometry
human serum
Humans
Lipids - blood
Lung Diseases - blood
Lung Diseases - chemically induced
Lung Diseases - diagnosis
Magnetic Resonance Spectroscopy
Male
Metabolomics
Middle Aged
Mustard Gas - toxicity
nuclear magnetic resonance
Pilot Projects
sulfur mustard
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Summary:Sulfur mustard (SM) is a potent alkylating agent and its effects on cells and tissues are varied and complex. Due to limitations in the diagnostics of sulfur mustard exposed individuals (SMEIs) by noninvasive approaches, there is a great necessity to develop novel techniques and biomarkers for this condition. We present here the first nuclear magnetic resonance (NMR) and gas chromatography-mass spectrometry (GC/MS) metabolic profiling of serum from and healthy controls to identify novel biomarkers in blood serum for better diagnostics. Of note, SMEIs were exposed to SM 30 years ago and that differences between two groups could still be found. Pathways in which differences between SMEIs and healthy controls are observed are related to lipid metabolism, ketogenesis, tricarboxylic acid (TCA) cycle and amino acid metabolism.
ISSN:1354-750X
1366-5804
DOI:10.3109/1354750X.2016.1153725