Acid ceramidase 1 expression correlates with a better prognosis in ER-positive breast cancer

Objectives Ceramide and sphingosine mediate response to cancer therapy, inhibit cell growth and induce apoptosis in vitro. Only a few clinical data about the impact of ceramide and sphingosine iny vivo are available. We investigated the relevance of ceramide- and sphingosine-generating enzymes in br...

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Published in:Climacteric : the journal of the International Menopause Society 2009-12, Vol.12 (6), p.502-513
Main Authors: Ruckhäberle, E., Holtrich, U., Engels, K., Hanker, L., Gätje, R., Metzler, D., Karn, T., Kaufmann, M., Rody, A.
Format: Article
Language:English
Subjects:
Acid Ceramidase - genetics
Acid Ceramidase 1
Breast Cancer
Breast Neoplasms - chemistry
Breast Neoplasms - enzymology
Breast Neoplasms - pathology
Enzymes
Estrogens
Female
Gene Expression
Genes, erbB-2 - genetics
Humans
Immunohistochemistry
LASS4
LASS6
Medical prognosis
Menopause
Microarray
Middle Aged
Oligonucleotide Array Sequence Analysis
Oxidoreductases - genetics
Prognosis
Proportional Hazards Models
Receptors, Estrogen - analysis
RNA, Messenger - analysis
Sphingolipid
Sphingolipids - metabolism
Women
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Summary:Objectives Ceramide and sphingosine mediate response to cancer therapy, inhibit cell growth and induce apoptosis in vitro. Only a few clinical data about the impact of ceramide and sphingosine iny vivo are available. We investigated the relevance of ceramide- and sphingosine-generating enzymes in breast cancer (acid ceramidase 1 (ASAH1), ceramide synthases 4 (LASS4) and 6 (LASS6)) by means of gene expression analysis. Methods We analyzed differences in ASAH1, LASS4 and LASS6 on mRNA level between breast cancer subgroups using microarray data from 1581 tumor samples. Results High ASAH1, LASS4 and LASS6 expression correlates with pathohistological grading (p 
ISSN:1369-7137
1473-0804
DOI:10.3109/13697130902939913