Micronutrients, their potential effect on patients with systemic sclerosis

Abstract Over the past years, several evidences have supported an important role of specific micronutrients, including vitamin A, vitamin D and vitamin E in immune dysfunction, vascular involvement and fibrotic changes involved in systemic sclerosis (SSc) development. In PubMed, eight clinical trial...

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Bibliographic Details
Published in:Modern rheumatology 2014-09, Vol.24 (5), p.709-714
Main Authors: Wan, Ya-Nan, Yan, Jun-Wei, Peng, Wen-Jia, Zhang, Jun-Qing, Xiao, Chang-Chun, Wang, Bing-Xiang, Wang, Jing
Format: Article
Language:English
Subjects:
Autoimmune diseases
Clinical trials
Dietary supplements
Humans
Immunology
Micronutrient
Micronutrients - therapeutic use
Multiple sclerosis
Nutrition research
Scleroderma, Systemic - drug therapy
Systemic sclerosis
Therapy
Treatment Outcome
Vitamin
Vitamins
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Summary:Abstract Over the past years, several evidences have supported an important role of specific micronutrients, including vitamin A, vitamin D and vitamin E in immune dysfunction, vascular involvement and fibrotic changes involved in systemic sclerosis (SSc) development. In PubMed, eight clinical trials about the therapy of micronutrients on SSc patients were searched out using medical subject headings terms (SSc: "scleroderma, localized", "scleroderma, systemic", "scleroderma, diffuse" and "scleroderma, limited"; vitamins "vitamin A", "thiamin", "riboflavin", "niacin", "pantothenic acid", "vitamin B 6", "biotin", "folic acid", "vitamin B 12", "inositol", "choline", "ascorbic acid", "vitamin D", "vitamin E", "tocopherols", "vitamin K" and "vitamin P"; and minerals: "calcium", "magnesium", "potassium", "sodium", "phosphorus", "sulfur", "chlorine", "iron", "copper", "iodine", "zinc", "selenium", "manganese", "molybdenum", "cobalt", "chromium", "tin", "vanadium", "silicon", "nickel" and "fluorine"). This brief review will summarize current understanding on that for the further prospect of future studies. Though the clinical trials for the treatment of SSc with micronutrients are still in their infancy, more researches are needed to substantiate the current results and accelerate the knowledge in this field.
ISSN:1439-7595
1439-7609
DOI:10.3109/14397595.2013.844383