Assessment of interleukin-6, interleukin-8 and interleukin-18 count in the serum of IUGR newborns

• Published in: The journal of maternal-fetal & neonatal medicine 2014-07, Vol.27 (11), p.1142-1145
• Main Authors: Krajewski, Pawel, Sieroszewski, Piotr, Karowicz-Bilinska, Agata, Kmiecik, Magdalena, Chudzik, Anita, Strzalko-Gloskowska, Barbara, Kwiatkowska, Maria, Pokrzywnicka, Malgorzata, Wyka, Krystyna, Chlapinski, Jakub, Kaminski, Marek, Wieckowska, Katarzyna
• Format: Article
• Language: English
• Subjects: AGA; Apgar Score; Case-Control Studies; Female; Fetal Growth Retardation - blood; Humans; IL-18; IL-6; IL-8; Infant, Newborn; Infant, Small for Gestational Age - blood; inflammation; Interleukin-18 - blood; Interleukin-6 - blood; Interleukin-8 - blood; IUGR; Pregnancy; Pregnancy Complications, Infectious - blood; Term Birth
• ISSN: 1476-7058; 1476-4954
• DOI: 10.3109/14767058.2013.851186

Abstract Aim: Aim of this study was to assess concentrations of interleukin-6 (IL-6), interleukin-8 (IL-8) and interleukin-18 (IL-18) in the serum of newborns with diagnosed intrauterine growth restriction (IUGR) in comparison to concentrations in serum of newborns with weight appropriate for gestational age (AGA). Materials: Research was conducted at the Lodz Medical University Clinic of Neonatology during 2010-2011. Surveyed group consisted of 50 hypotrophic full-term infants of single pregnancies (average weight: 2329 ± 287 g); control group, enclosing 50 infants AGA (average weight: 3544 ± 2161 g). Both groups received average Apgar score of 9 points. Concentrations of analysed cytokines were marked between 4-6 hours after birth. The enzyme-linked immunosorbent assay (ELISA) test was used to determine interleukins concentrations. Study was prospective. Statistics on the data were conducted with the Kolmogorov-Smirnov test. Significance level: p