The evaluation of Nesfatin-1 levels in patients with and without intrauterine growth restriction

• Published in: The journal of maternal-fetal & neonatal medicine 2016-05, Vol.29 (9), p.1409-1413
• Main Authors: Serin, Salih, Bakacak, Murat, Ercan, Önder, Köstü, Bülent, Avci, Fazıl, Arıkan, Deniz, Kıran, Gürkan
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Calcium-Binding Proteins - blood; Case-Control Studies; DNA-Binding Proteins - blood; Female; Fetal Growth Retardation - blood; Fetal weight; Humans; intrauterine growth restriction; Middle Aged; Nerve Tissue Proteins - blood; Nesfatin-1; Pregnancy; Young Adult
• ISSN: 1476-7058; 1476-4954
• DOI: 10.3109/14767058.2015.1049524

Objective: To evaluate Nesfatin-1 levels in patients with and without intrauterine growth restriction and to analyze the correlation between Nesfatin-1 levels and fetal birth weights. Methods: This study comprised a total of 81 cases; 41 patients with IUGR and 40 healthy cases. Demographic data, pregnancy weeks, fetal birth weights and Nesfatin-1 levels were all recorded. The Nesfatin-1 levels were compared between the groups and the correlation between fetal birth weights and Nesfatin-1 levels was analyzed. Results: No statistical significant difference was determined between the groups in terms of demographic data (p > 0.05). Average birth weights were determined as 3420 ± 259 g in the control group and 2041 ± 350 g in the IUGR group, which was found to be statistically unequal (p = 0.001). The average Nesfatin levels in the control group were 0.069 ± 0.011 and 0.094 ± 0.042 in the IUGR group. This difference was statistically unequal (p = 0.001). While no correlation was determined between Nesfatin levels and fetal birthweights in the control group (r = −0.034 versus p = 0.836), in the IUGR group and when all the cases were evaluated together, a statistically moderately significant negative correlation was determined (r = −0.469, p = 0.002 and r = −0.251, p = 0.024, respectively). Conclusions: Although intrauterine growth is a multifactorial process, the effect mechanism has not yet been established. The results of this study offer some indications about the possible effect of Nesfatin 1 on fetal growth.