Replacing risk-based early-onset-disease prevention with intrapartum group B streptococcus PCR testing

Objective: To evaluate the effect of a rapid PCR-based group B streptococcus (GBS) test on length of stay in hospital among newborns, antibiotic use, and GBS-early-onset-disease (EOD) incidence. Methods: We conducted a before and after service evaluation including term deliveries between 1st January...

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Bibliographic Details
Published in:The journal of maternal-fetal & neonatal medicine 2017-02, Vol.30 (3), p.368-373
Main Authors: Björklund, V., Nieminen, T., Ulander, V. M., Ahola, T., Saxén, H.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - therapeutic use
Antibiotic Prophylaxis
Female
GBS early onset disease
group B streptococcus
Humans
Incidence
Infant, Newborn
Infectious Disease Transmission, Vertical - prevention & control
Length of Stay - statistics & numerical data
neonates
observational study
Penicillin G - therapeutic use
Perinatal Care - methods
Point-of-Care Systems
Polymerase Chain Reaction
Pregnancy
Pregnancy Complications, Infectious - diagnosis
Pregnancy Complications, Infectious - epidemiology
Pregnancy Complications, Infectious - prevention & control
rapid diagnostic test
Risk Assessment
Streptococcal Infections - diagnosis
Streptococcal Infections - epidemiology
Streptococcal Infections - prevention & control
Streptococcal Infections - transmission
Streptococcus agalactiae - genetics
Streptococcus agalactiae - isolation & purification
Treatment Outcome
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Summary:Objective: To evaluate the effect of a rapid PCR-based group B streptococcus (GBS) test on length of stay in hospital among newborns, antibiotic use, and GBS-early-onset-disease (EOD) incidence. Methods: We conducted a before and after service evaluation including term deliveries between 1st January and 12th November 2014 (6688 deliveries). Length of stay in the hospital, GBS-EOD incidence and antibiotic use were evaluated. Results: We recorded three confirmed and 74 possible cases of GBS-EOD in Phase 1, and 85 possible cases in Phase 2. In newborns with suspected infection, the introduction of the rapid test was related to a decreased length of stay on the pediatric care unit by 1.16 days (p = 0.01), and an increase in the length of stay on the mother-and-baby ward by 1.11 days (p 
ISSN:1476-7058
1476-4954
DOI:10.3109/14767058.2016.1173030