Expression of Stem Cell Markers, CD133 and CD44, in Pediatric Solid Tumors: A Study Using Tissue Microarray

Based on the cancer stem cell (CSC) concept model, a small population of cells with unique self-renewal properties and malignant potential exists in tumors. Immunohistochemistry was performed to detect the expression of CSC markers, CD133 and CD44, in a series of pediatric tumors. The association be...

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Bibliographic Details
Published in:Fetal and pediatric pathology 2013-06, Vol.32 (3), p.192-204
Main Authors: Mehrazma, Mitra, Madjd, Zahra, Kalantari, Elham, Panahi, Mahshid, Hendi, Alireza, Shariftabrizi, Ahmad
Format: Article
Language:English
Subjects:
AC133 Antigen
Antigens, CD - metabolism
Biomarkers, Tumor - metabolism
cancer stem cells (CSC)
CD133
CD44
Child
Child, Preschool
Female
Glycoproteins - metabolism
Hodgkin Disease - metabolism
Hodgkin Disease - pathology
Hodgkin Disease - surgery
Humans
Hyaluronan Receptors - metabolism
Infant
Kidney Neoplasms - metabolism
Kidney Neoplasms - pathology
Kidney Neoplasms - surgery
Male
Neoplasm Staging
Neuroblastoma - metabolism
Neuroblastoma - pathology
Neuroblastoma - surgery
pediatric solid tumors
Peptides - metabolism
Prognosis
Retrospective Studies
Stem Cells - metabolism
Stem Cells - pathology
Tissue Array Analysis
Wilms Tumor - metabolism
Wilms Tumor - pathology
Wilms Tumor - surgery
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Summary:Based on the cancer stem cell (CSC) concept model, a small population of cells with unique self-renewal properties and malignant potential exists in tumors. Immunohistochemistry was performed to detect the expression of CSC markers, CD133 and CD44, in a series of pediatric tumors. The association between expression of these markers and tumor characteristics was then analyzed. In Wilms tumors (WT), a significant positive correlation was found between expression of CD133 and the National Wilms Tumor Stage (NWTS) (p = 0.047). In neuroblastomas (NB), expression of CD133 was positively correlated with the International Neuroblastoma Staging System (INSS) (p-value = 0.012), indicating that the rate of CD133 positivity increased with the stage of these tumors. CD133, as a putative stem cell marker, is associated with more advanced stages of Wilms and NB tumors; therefore, this molecule can be a potential clinical prognostic marker in children suffering from NB or Wilms tumor.
ISSN:1551-3815
1551-3823
DOI:10.3109/15513815.2012.701266