Combination of azelaic acid 5% and clindamycin 2% for the treatment of acne vulgaris

Context and objective: Acne vulgaris, an inflammatory skin disease with different clinical appearances, is a common problem in most adolescents. It seems that using combinations of topical agents can decrease resistance to the treatment and improve the efficacy. Therefore, we evaluated the effects o...

Full description

Saved in:
Bibliographic Details
Published in:Cutaneous and ocular toxicology 2011-12, Vol.30 (4), p.286-291
Main Authors: Pazoki-Toroudi, Hamidreza, Nilforoushzadeh, Mohamad Ali, Ajami, Marjan, Jaffary, Fariba, Aboutaleb, Nahid, Nassiri-Kashani, Mansour, Firooz, Alireza
Format: Article
Language:English
Subjects:
acne vulgaris
Acne Vulgaris - drug therapy
Administration, Topical
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - therapeutic use
azelaic acid
clindamycin
Clindamycin - administration & dosage
Clindamycin - adverse effects
Clindamycin - therapeutic use
Dermatologic Agents - administration & dosage
Dermatologic Agents - adverse effects
Dermatologic Agents - therapeutic use
Dicarboxylic Acids - administration & dosage
Dicarboxylic Acids - adverse effects
Dicarboxylic Acids - therapeutic use
Dose-Response Relationship, Drug
Double-Blind Method
Drug Therapy, Combination
Female
Humans
Male
Patient Satisfaction
Time Factors
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Context and objective: Acne vulgaris, an inflammatory skin disease with different clinical appearances, is a common problem in most adolescents. It seems that using combinations of topical agents can decrease resistance to the treatment and improve the efficacy. Therefore, we evaluated the effects of azelaic acid (AA) 5% and clindamycin (Clin) 2% combination (AA-Clin) on mild-to-moderate acne vulgaris. Materials and methods: The efficacy and safety of 12-week treatment with AA-Clin in patients with mild-to-moderate facial acne vulgaris were evaluated by a multicenter, randomized, and double-blind study. A total of 88 male and 62 female patients were randomly assigned to one of these treatments: AA 5%, Clin 2%, and combination of them. Every 4 weeks, total inflammatory and noninflammatory lesions were counted, acne severity index (ASI) was calculated, and patient satisfaction was recorded. Results: Treatment for 12 weeks with combination gel significantly reduced the total lesion number compared with baseline (p 
ISSN:1556-9527
1556-9535
DOI:10.3109/15569527.2011.581257