Enoxaparin-induced hemorrhagic bullous dermatosis in a leprosy patient

Enoxaparin is a low-molecular-weight heparin that has been used widely to prevent and treat thromboembolic disorders for at least 30 years. The most common adverse skin reactions to enoxaparin are ecchymosis and skin necrosis due to vasculitis, urticaria, angioedema and erythema. Side effects from h...

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Bibliographic Details
Published in:Cutaneous and ocular toxicology 2015-01, Vol.34 (3), p.254-256
Main Authors: Öztürk, Savaş, Can, Ilkay, Erden, Ilker, Akyol, Hadice, Solmaz, Ozgen Aslan
Format: Article
Language:English
Subjects:
Aged
Anticoagulants - adverse effects
Enoxaparin - adverse effects
Humans
Leprosy - complications
Male
Myocardial Ischemia - complications
Myocardial Ischemia - drug therapy
Skin Diseases, Vesiculobullous - chemically induced
Skin Diseases, Vesiculobullous - complications
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Summary:Enoxaparin is a low-molecular-weight heparin that has been used widely to prevent and treat thromboembolic disorders for at least 30 years. The most common adverse skin reactions to enoxaparin are ecchymosis and skin necrosis due to vasculitis, urticaria, angioedema and erythema. Side effects from heparin administration are rare and usually located at the injection site. However, recent reports have suggested that they can also occur at a distance from the site of injection. Moreover, the etiopathogenesis has not been fully explained. In this article, we present a case of hemorrhagic bullous dermatosis associated with enoxaparin for the treatment of ischemic heart disease that developed in a patient with a past history of lepromatous leprosy.
ISSN:1556-9527
1556-9535
DOI:10.3109/15569527.2014.950381