Toxic evaluation of the alkylmethylimidazolium-based ionic liquids in yeast Saccharomyces cerevisiae by flow cytometry

Ionic liquids (ILs) have gained considerable attention in recent years due to their properties and have been used in different chemical processes. In case ILs are released to the environment, their possible toxicity should be taken into account. In this paper, the cytotoxicity of alkylmethylimidazol...

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Bibliographic Details
Published in:Toxin reviews 2012-11, Vol.31 (3-4), p.27-31
Main Authors: Jing, Chang-Qin, Liu, Yong-Tao, Shen, Xiang-Yu, Li, Long, Gao, Qi-Yu, Yu, Yi
Format: Article
Language:English
Subjects:
flow cytometry
Ionic liquids
Saccharomyces cerevisiae
toxic evaluation
yeast
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Summary:Ionic liquids (ILs) have gained considerable attention in recent years due to their properties and have been used in different chemical processes. In case ILs are released to the environment, their possible toxicity should be taken into account. In this paper, the cytotoxicity of alkylmethylimidazolium-based ionic liquids in yeast Saccharomyces cerevisiae was determined by flow cytometry. The validity of flow cytometry in viability analyses in yeast Saccharomyces cerevisiae was determined and the results showed that flow cytometry lends itself well to the determination and quantitation of yeast viability. The results also indicate that ILs with longer alkyl-chain length had stronger cytotoxicity and the cytotoxicity of the ILs was in a dose-dependent and time-dependent manner.
ISSN:1556-9543
1556-9551
DOI:10.3109/15569543.2012.730091