The Activity of β-Hexosaminidase (uHex) and γ-Glutamyl-Transferase (uGGT) in Urine as Non-Invasive Markers of Chronic Alcohol Abuse: I. Alcohol-Dependent Subjects

It has been demonstrated that in alcohol-dependent men the uHex test is one of the most powerful discriminating tools, while uGGT has a discriminating power similar to that of sHex but worse than that of uHex, sGGT and s%CDT. Receiver Operating Characteristic (ROC) areas under the curves (AUC) for u...

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Bibliographic Details
Published in:The world journal of biological psychiatry 2001, Vol.2 (4), p.184-189
Main Authors: Taracha, Ewa, Habrat, Boguslaw, Wo iak, Piotr, Walkowiak, Jerzy, Szukalski, Bogdan
Format: Article
Language:English
Subjects:
Adult
Alcoholism - diagnosis
Alcoholism - enzymology
Alcoholism - rehabilitation
beta-N-Acetylhexosaminidases - metabolism
beta-N-Acetylhexosaminidases - urine
biological markers of alcohol abuse
Biomarkers
CDT
gamma-Glutamyltransferase - metabolism
gamma-Glutamyltransferase - urine
Humans
Inactivation, Metabolic
Male
Middle Aged
ROC Curve
Sensitivity and Specificity
serum γ-glutamyltransferase
urine β-hexosaminidase
urine γ-glutamyltransferase
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Summary:It has been demonstrated that in alcohol-dependent men the uHex test is one of the most powerful discriminating tools, while uGGT has a discriminating power similar to that of sHex but worse than that of uHex, sGGT and s%CDT. Receiver Operating Characteristic (ROC) areas under the curves (AUC) for uHex, uGGT, s%CDT, sHex and sGGT were 0.92, 0.79, 0.88, 0.79 and 0.92, respectively. Due to their good parameters, low cost, ease of use and noninvasive character the uHex and uGGT tests are useful tools for the detection of chronic alcohol abuse.
ISSN:1562-2975
1814-1412
DOI:10.3109/15622970109026807