The Activity of β-Hexosaminidase (uHex) and γ-Glutamyl-Transferase (uGGT) in Urine as Non-Invasive Markers of Chronic Alcohol Abuse: I. Alcohol-Dependent Subjects

It has been demonstrated that in alcohol-dependent men the uHex test is one of the most powerful discriminating tools, while uGGT has a discriminating power similar to that of sHex but worse than that of uHex, sGGT and s%CDT. Receiver Operating Characteristic (ROC) areas under the curves (AUC) for u...

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Published in:The world journal of biological psychiatry 2001, Vol.2 (4), p.184-189
Main Authors: Taracha, Ewa, Habrat, Boguslaw, Wo iak, Piotr, Walkowiak, Jerzy, Szukalski, Bogdan
Format: Article
Language:English
Subjects:
Adult
Alcoholism - diagnosis
Alcoholism - enzymology
Alcoholism - rehabilitation
beta-N-Acetylhexosaminidases - metabolism
beta-N-Acetylhexosaminidases - urine
biological markers of alcohol abuse
Biomarkers
CDT
gamma-Glutamyltransferase - metabolism
gamma-Glutamyltransferase - urine
Humans
Inactivation, Metabolic
Male
Middle Aged
ROC Curve
Sensitivity and Specificity
serum γ-glutamyltransferase
urine β-hexosaminidase
urine γ-glutamyltransferase
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cited_by cdi_FETCH-LOGICAL-c317t-4b5243c61f3aee5d1a2d225e1066e44d0ce1e387470cb348385570663a9776623
cites cdi_FETCH-LOGICAL-c317t-4b5243c61f3aee5d1a2d225e1066e44d0ce1e387470cb348385570663a9776623
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container_issue 4
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container_title The world journal of biological psychiatry
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creator Taracha, Ewa
Habrat, Boguslaw
Wo iak, Piotr
Walkowiak, Jerzy
Szukalski, Bogdan
description It has been demonstrated that in alcohol-dependent men the uHex test is one of the most powerful discriminating tools, while uGGT has a discriminating power similar to that of sHex but worse than that of uHex, sGGT and s%CDT. Receiver Operating Characteristic (ROC) areas under the curves (AUC) for uHex, uGGT, s%CDT, sHex and sGGT were 0.92, 0.79, 0.88, 0.79 and 0.92, respectively. Due to their good parameters, low cost, ease of use and noninvasive character the uHex and uGGT tests are useful tools for the detection of chronic alcohol abuse.
doi_str_mv 10.3109/15622970109026807
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ispartof The world journal of biological psychiatry, 2001, Vol.2 (4), p.184-189
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source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)
subjects Adult
Alcoholism - diagnosis
Alcoholism - enzymology
Alcoholism - rehabilitation
beta-N-Acetylhexosaminidases - metabolism
beta-N-Acetylhexosaminidases - urine
biological markers of alcohol abuse
Biomarkers
CDT
gamma-Glutamyltransferase - metabolism
gamma-Glutamyltransferase - urine
Humans
Inactivation, Metabolic
Male
Middle Aged
ROC Curve
Sensitivity and Specificity
serum γ-glutamyltransferase
urine β-hexosaminidase
urine γ-glutamyltransferase
title The Activity of β-Hexosaminidase (uHex) and γ-Glutamyl-Transferase (uGGT) in Urine as Non-Invasive Markers of Chronic Alcohol Abuse: I. Alcohol-Dependent Subjects
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