Interaction between serotonin 5-HT2A receptor gene and dopamine transporter (DAT1) gene polymorphisms influences personality trait of persistence in Austrian Caucasians

We examined 89 normal volunteers using Cloninger's Temperament and Character Inventory (TCI). Genotyping the 102T/C polymorphism of the serotonin 5HT2A receptor gene and the ser9gly polymorphism in exon 1 of the dopamine D3 receptor (DRD3) gene was performed using PCR-RFLP, whereas the dopamine...

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Bibliographic Details
Published in:The world journal of biological psychiatry 2010-03, Vol.11 (2_2), p.417-424
Main Authors: Schosser, Alexandra, Fuchs, Karoline, Scharl, Theresa, Schloegelhofer, Monika, Kindler, Jochen, Mossaheb, Nilufar, Kaufmann, Rainer M., Leisch, Friedrich, Kasper, Siegfried, Sieghart, Werner, Aschauer, Harald N.
Format: Article
Language:English
Subjects:
5HT2A
Adult
Alleles
Austria
DAT1
Dopamine Plasma Membrane Transport Proteins - genetics
DRD3
European Continental Ancestry Group - genetics
European Continental Ancestry Group - psychology
Exploratory Behavior
Female
Genotype
Harm Reduction
Heterozygote
Homozygote
Humans
Male
Minisatellite Repeats - genetics
personality
Personality - genetics
Polymerase Chain Reaction
Polymorphism, Genetic - genetics
Polymorphism, Single Nucleotide - genetics
Receptor, Serotonin, 5-HT2A - genetics
Receptors, Dopamine D3 - genetics
Sex Factors
Statistics, Nonparametric
TCI
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Summary:We examined 89 normal volunteers using Cloninger's Temperament and Character Inventory (TCI). Genotyping the 102T/C polymorphism of the serotonin 5HT2A receptor gene and the ser9gly polymorphism in exon 1 of the dopamine D3 receptor (DRD3) gene was performed using PCR-RFLP, whereas the dopamine transporter (DAT1) gene variable number of tandem repeats (VNTR) polymorphism was investigated using PCR amplification followed by electrophoresis in an 8% acrylamide gel with a set of size markers. We found a nominally significant association between gender and harm avoidance (P=0.017; women showing higher scores). There was no association of either DAT1, DRD3 or 5HT2A alleles or genotypes with any dimension of the TCI applying Kruskal-Wallis rank-sum tests. Comparing homozygote and heterozygote DAT1 genotypes, we found higher novelty seeking scores in homozygotes (P=0.054). We further found a nominally significant interaction between DAT1 and 5HT2A homo-/heterozygous gene variants (P=0.0071; DAT1 and 5HT2A genotypes P value of 0.05), performing multivariate analysis of variance (MANOVA). Examining the temperamental TCI subscales, this interaction was associated with persistence (genotypes: P=0.004; homo-/heterozygous gene variants: P=0.0004). We conclude that an interaction between DAT1 and 5HT2A genes might influence the temperamental personality trait persistence.
ISSN:1562-2975
1814-1412
DOI:10.3109/15622970801935586