Self-poisonings with tricyclic antidepressants and selective serotonin reuptake inhibitors in Tehran, Iran

In a prospective hospital-based cohort study, we addressed the question of severity and outcome of antidepressant poisonings in patients who attended the Loghman-Hakim Hospital Poison Center, the only national center in Tehran dedicated for detoxification. The aim of the study was to find out if tri...

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Bibliographic Details
Published in:The world journal of biological psychiatry 2009, Vol.10 (4), p.302-312
Main Authors: Naderi-Heiden, Angela, Shadnia, Shahin, Salimi, Ali-Reza, Naderi, Ahmad, Naderi, Mohammad M., Schmid, Daniela, Gleiss, Andreas, Kasper, Siegfried, Frey, Richard
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antidepressive Agents, Second-Generation - poisoning
Antidepressive Agents, Tricyclic - poisoning
Cohort Studies
coma
Coma - chemically induced
Coma - epidemiology
Cross-Sectional Studies
Drug Interactions
Drug Overdose - epidemiology
Female
Humans
intoxications
intubation
Intubation, Intratracheal - statistics & numerical data
Iran
Lithium Carbonate - poisoning
Male
Middle Aged
Patient Admission - statistics & numerical data
Poison Control Centers - statistics & numerical data
Poisoning - epidemiology
Prospective Studies
Psychotropic Drugs - poisoning
selective serotonin reuptake inhibitors (SSRIs)
Serotonin Uptake Inhibitors - poisoning
Suicide, Attempted - statistics & numerical data
Tricyclic antidepressants (TCAs)
Young Adult
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Summary:In a prospective hospital-based cohort study, we addressed the question of severity and outcome of antidepressant poisonings in patients who attended the Loghman-Hakim Hospital Poison Center, the only national center in Tehran dedicated for detoxification. The aim of the study was to find out if tricyclic antidepressant (TCA) intoxications require more therapeutic efforts than selective serotonin reuptake inhibitor (SSRI) intoxications. The study was applied over a 7-week period (28 March-20 May 2006). From 3578 intoxications, 334 patients with antidepressant or lithium self-poisoning were identified (9.3% of all poisoning cases; 233 females, 101 males; median age 24 years, min 13, max 70). Compared to SSRI single-substance intoxications (n=17), TCA single-substance intoxications (n=73) were associated with: (1) a significantly lower level of consciousness (P=0.005); (2) a significantly higher admission frequency (80.8 vs. 35.3%; P
ISSN:1562-2975
1814-1412
DOI:10.3109/15622970802288563