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Bioaccumulation of ionic titanium and titanium dioxide nanoparticles in zebrafish eleutheroembryos
The production of titanium dioxide nanoparticles (TiO 2 NPs) for commercial applications has greatly increased over the last years and consequently the potential risk for human health. There is a growing awareness of the need to understand the behavior and influence these nanoparticles exert on the...
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| Published in: | Nanotoxicology 2015-01, Vol.9 (7), p.835-842 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c512t-1366a4e79506650cf56dba7f516978cf4d13868960ee440b20c2fc83b452323c3 |
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| container_title | Nanotoxicology |
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| creator | López-Serrano Oliver, Ana Muñoz-Olivas, Riansares Sanz Landaluze, Jon Rainieri, Sandra Cámara, Carmen |
| description | The production of titanium dioxide nanoparticles (TiO
2
NPs) for commercial applications has greatly increased over the last years and consequently the potential risk for human health. There is a growing awareness of the need to understand the behavior and influence these nanoparticles exert on the environment. Bioaccumulation serves as a good integrator to assess chemical exposure in aquatic systems and is dependent on factors, such as the exposure routes, diet and the aqueous medium. We analyzed the experimental bioaccumulation capability of ionic titanium and TiO
2
NPs by zebrafish (Danio rerio) eleutheroembryos through bioconcentration factors (BCFs), after 48 or 72 h of exposure. The stability of both chemical forms in an aquatic medium was fully characterized for further bioaccumulation studies. Several stabilizing agents (humic acids, soluble starch, polyethylene glycol, Na
4
P
2
O
7
and Na
2
HPO
4
) for anatase and rutile, the two allotrophs of TiO
2
NPs, were evaluated to check the evolution of the aggregation process. Around 60% of TiO
2
NPs remained disaggregated under simulated environmental conditions with the addition of 50 mg L
−1
of humic acids. However, the presence of eleutheroembryos in the exposure medium increased TiO
2
NPs aggregation in the experimental tests. The BCFs values obtained in all cases were |
| doi_str_mv | 10.3109/17435390.2014.980758 |
| format | article |
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2
NPs) for commercial applications has greatly increased over the last years and consequently the potential risk for human health. There is a growing awareness of the need to understand the behavior and influence these nanoparticles exert on the environment. Bioaccumulation serves as a good integrator to assess chemical exposure in aquatic systems and is dependent on factors, such as the exposure routes, diet and the aqueous medium. We analyzed the experimental bioaccumulation capability of ionic titanium and TiO
2
NPs by zebrafish (Danio rerio) eleutheroembryos through bioconcentration factors (BCFs), after 48 or 72 h of exposure. The stability of both chemical forms in an aquatic medium was fully characterized for further bioaccumulation studies. Several stabilizing agents (humic acids, soluble starch, polyethylene glycol, Na
4
P
2
O
7
and Na
2
HPO
4
) for anatase and rutile, the two allotrophs of TiO
2
NPs, were evaluated to check the evolution of the aggregation process. Around 60% of TiO
2
NPs remained disaggregated under simulated environmental conditions with the addition of 50 mg L
−1
of humic acids. However, the presence of eleutheroembryos in the exposure medium increased TiO
2
NPs aggregation in the experimental tests. The BCFs values obtained in all cases were <100, which classifies ionic titanium and TiO
2
NPs as non-bioaccumulative substances, under the REACH regulations.</description><identifier>ISSN: 1743-5390</identifier><identifier>EISSN: 1743-5404</identifier><identifier>DOI: 10.3109/17435390.2014.980758</identifier><identifier>PMID: 25405263</identifier><language>eng</language><publisher>England: Informa Healthcare</publisher><subject>Aggregation ; Animals ; bioaccumulation ; Danio rerio ; Drug Stability ; Freshwater ; Humans ; Nanoparticles - metabolism ; stability ; Titanium - chemistry ; Titanium - pharmacokinetics ; titanium dioxide nanoparticles ; Zebrafish - embryology ; Zebrafish - metabolism ; zebrafish eleutheroembryos</subject><ispartof>Nanotoxicology, 2015-01, Vol.9 (7), p.835-842</ispartof><rights>2014 Informa UK Ltd. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-1366a4e79506650cf56dba7f516978cf4d13868960ee440b20c2fc83b452323c3</citedby><cites>FETCH-LOGICAL-c512t-1366a4e79506650cf56dba7f516978cf4d13868960ee440b20c2fc83b452323c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25405263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>López-Serrano Oliver, Ana</creatorcontrib><creatorcontrib>Muñoz-Olivas, Riansares</creatorcontrib><creatorcontrib>Sanz Landaluze, Jon</creatorcontrib><creatorcontrib>Rainieri, Sandra</creatorcontrib><creatorcontrib>Cámara, Carmen</creatorcontrib><title>Bioaccumulation of ionic titanium and titanium dioxide nanoparticles in zebrafish eleutheroembryos</title><title>Nanotoxicology</title><addtitle>Nanotoxicology</addtitle><description>The production of titanium dioxide nanoparticles (TiO
2
NPs) for commercial applications has greatly increased over the last years and consequently the potential risk for human health. There is a growing awareness of the need to understand the behavior and influence these nanoparticles exert on the environment. Bioaccumulation serves as a good integrator to assess chemical exposure in aquatic systems and is dependent on factors, such as the exposure routes, diet and the aqueous medium. We analyzed the experimental bioaccumulation capability of ionic titanium and TiO
2
NPs by zebrafish (Danio rerio) eleutheroembryos through bioconcentration factors (BCFs), after 48 or 72 h of exposure. The stability of both chemical forms in an aquatic medium was fully characterized for further bioaccumulation studies. Several stabilizing agents (humic acids, soluble starch, polyethylene glycol, Na
4
P
2
O
7
and Na
2
HPO
4
) for anatase and rutile, the two allotrophs of TiO
2
NPs, were evaluated to check the evolution of the aggregation process. Around 60% of TiO
2
NPs remained disaggregated under simulated environmental conditions with the addition of 50 mg L
−1
of humic acids. However, the presence of eleutheroembryos in the exposure medium increased TiO
2
NPs aggregation in the experimental tests. The BCFs values obtained in all cases were <100, which classifies ionic titanium and TiO
2
NPs as non-bioaccumulative substances, under the REACH regulations.</description><subject>Aggregation</subject><subject>Animals</subject><subject>bioaccumulation</subject><subject>Danio rerio</subject><subject>Drug Stability</subject><subject>Freshwater</subject><subject>Humans</subject><subject>Nanoparticles - metabolism</subject><subject>stability</subject><subject>Titanium - chemistry</subject><subject>Titanium - pharmacokinetics</subject><subject>titanium dioxide nanoparticles</subject><subject>Zebrafish - embryology</subject><subject>Zebrafish - metabolism</subject><subject>zebrafish eleutheroembryos</subject><issn>1743-5390</issn><issn>1743-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqNkUtLxDAUhYMozjj6D0S6dNMx77Yr0cEXDLjRdUjThIm0yZik6PjrbZkZ3Ymr--A798A9AJwjOCcIVleooISRCs4xRHRelbBg5QGYjuucUUgP9_3ATMBJjG8QMo45OgYTPAAMczIF9a31Uqm-61uZrHeZN9lQrMqSTdLZvsuka36HxvpP2-jMSefXMiSrWh0z67IvXQdpbFxlutV9WungdVeHjY-n4MjINuqzXZ2B1_u7l8Vjvnx-eFrcLHPFEE45IpxLqouKQc4ZVIbxppaFYYhXRakMbRApeVlxqDWlsMZQYaNKUlOGCSaKzMDl9u46-PdexyQ6G5VuW-m076NABWEVKiDk_0AHU1KWFRpQukVV8DEGbcQ62E6GjUBQjEGIfRBiDEJsgxhkFzuHvu508yPaf34ArreAdcaHTn740DYiyU3rgwnSKRvH839YfAPSkpfN</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>López-Serrano Oliver, Ana</creator><creator>Muñoz-Olivas, Riansares</creator><creator>Sanz Landaluze, Jon</creator><creator>Rainieri, Sandra</creator><creator>Cámara, Carmen</creator><general>Informa Healthcare</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope></search><sort><creationdate>20150101</creationdate><title>Bioaccumulation of ionic titanium and titanium dioxide nanoparticles in zebrafish eleutheroembryos</title><author>López-Serrano Oliver, Ana ; Muñoz-Olivas, Riansares ; Sanz Landaluze, Jon ; Rainieri, Sandra ; Cámara, Carmen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-1366a4e79506650cf56dba7f516978cf4d13868960ee440b20c2fc83b452323c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aggregation</topic><topic>Animals</topic><topic>bioaccumulation</topic><topic>Danio rerio</topic><topic>Drug Stability</topic><topic>Freshwater</topic><topic>Humans</topic><topic>Nanoparticles - metabolism</topic><topic>stability</topic><topic>Titanium - chemistry</topic><topic>Titanium - pharmacokinetics</topic><topic>titanium dioxide nanoparticles</topic><topic>Zebrafish - embryology</topic><topic>Zebrafish - metabolism</topic><topic>zebrafish eleutheroembryos</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>López-Serrano Oliver, Ana</creatorcontrib><creatorcontrib>Muñoz-Olivas, Riansares</creatorcontrib><creatorcontrib>Sanz Landaluze, Jon</creatorcontrib><creatorcontrib>Rainieri, Sandra</creatorcontrib><creatorcontrib>Cámara, Carmen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Nanotoxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>López-Serrano Oliver, Ana</au><au>Muñoz-Olivas, Riansares</au><au>Sanz Landaluze, Jon</au><au>Rainieri, Sandra</au><au>Cámara, Carmen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bioaccumulation of ionic titanium and titanium dioxide nanoparticles in zebrafish eleutheroembryos</atitle><jtitle>Nanotoxicology</jtitle><addtitle>Nanotoxicology</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>9</volume><issue>7</issue><spage>835</spage><epage>842</epage><pages>835-842</pages><issn>1743-5390</issn><eissn>1743-5404</eissn><abstract>The production of titanium dioxide nanoparticles (TiO
2
NPs) for commercial applications has greatly increased over the last years and consequently the potential risk for human health. There is a growing awareness of the need to understand the behavior and influence these nanoparticles exert on the environment. Bioaccumulation serves as a good integrator to assess chemical exposure in aquatic systems and is dependent on factors, such as the exposure routes, diet and the aqueous medium. We analyzed the experimental bioaccumulation capability of ionic titanium and TiO
2
NPs by zebrafish (Danio rerio) eleutheroembryos through bioconcentration factors (BCFs), after 48 or 72 h of exposure. The stability of both chemical forms in an aquatic medium was fully characterized for further bioaccumulation studies. Several stabilizing agents (humic acids, soluble starch, polyethylene glycol, Na
4
P
2
O
7
and Na
2
HPO
4
) for anatase and rutile, the two allotrophs of TiO
2
NPs, were evaluated to check the evolution of the aggregation process. Around 60% of TiO
2
NPs remained disaggregated under simulated environmental conditions with the addition of 50 mg L
−1
of humic acids. However, the presence of eleutheroembryos in the exposure medium increased TiO
2
NPs aggregation in the experimental tests. The BCFs values obtained in all cases were <100, which classifies ionic titanium and TiO
2
NPs as non-bioaccumulative substances, under the REACH regulations.</abstract><cop>England</cop><pub>Informa Healthcare</pub><pmid>25405263</pmid><doi>10.3109/17435390.2014.980758</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1743-5390 |
| ispartof | Nanotoxicology, 2015-01, Vol.9 (7), p.835-842 |
| issn | 1743-5390 1743-5404 |
| language | eng |
| recordid | cdi_crossref_primary_10_3109_17435390_2014_980758 |
| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Aggregation Animals bioaccumulation Danio rerio Drug Stability Freshwater Humans Nanoparticles - metabolism stability Titanium - chemistry Titanium - pharmacokinetics titanium dioxide nanoparticles Zebrafish - embryology Zebrafish - metabolism zebrafish eleutheroembryos |
| title | Bioaccumulation of ionic titanium and titanium dioxide nanoparticles in zebrafish eleutheroembryos |
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