Intrinsic properties and functional changes in spastic muscle after application of BTX-A in children with cerebral palsy: Systematic review

Abstract Objective: This article aimed to review the literature to verify the effect of botulinum toxin type A (BTX-A) on the intrinsic properties of spastic muscles and functionality in children with cerebral palsy (CP). Methods: A literature search was conducted in the following databases: CINAHL,...

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Published in:Developmental neurorehabilitation 2015-02, Vol.18 (1), p.1-14
Main Authors: García Salazar, Luisa Fernanda, Santos, Gabriela Lopes dos, Pavão, Silvia Letícia, Rocha, Nelci Adriana Cicuto Ferreira, Russo, Thiago Luiz de
Format: Article
Language:English
Subjects:
Adolescent
Botulinum toxin
Botulinum Toxins, Type A - administration & dosage
Botulinum Toxins, Type A - therapeutic use
Cerebral Palsy - drug therapy
Child
Child, Preschool
functionality
Humans
Injections, Intramuscular
motor developmental
muscle spasticity
Muscle Spasticity - drug therapy
Neuromuscular Agents - administration & dosage
Neuromuscular Agents - therapeutic use
rehabilitation
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Summary:Abstract Objective: This article aimed to review the literature to verify the effect of botulinum toxin type A (BTX-A) on the intrinsic properties of spastic muscles and functionality in children with cerebral palsy (CP). Methods: A literature search was conducted in the following databases: CINAHL, SCOPUS, Web of Science and PubMed. Database searches were limited to the period from January 1993 to March 2014. Results: A total of 2182 papers were identified, and 17 met the inclusion criteria. Only one study analyzed the effect of the toxin on muscle intrinsic properties and others analyzed the effect on functionality. Conclusion: BTX-A application demonstrated no changes in the passive stiffness of spastic muscle. In relation to functional level, the evidence of BTX-A effect was controversial. These studies showed methodological quality limitations that restrict the interpretation of the results for the entire CP population, which justifies the need for further randomized controlled trials.
ISSN:1751-8423
1751-8431
DOI:10.3109/17518423.2014.948640