Peripheral CD4+ T cells showing a Th2 phenotype in a patient with Mikulicz's disease associated with lymphadenopathy and pleural effusion

Abstract Mikulicz's disease (MD) is a unique IgG4-related systemic disease indicated by enlargement of the lachrymal and salivary glands and which differs substantially from Sjögren's syndrome. A male patient with pleural effusion, swelling of the submandibular glands, and swelling of the...

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Bibliographic Details
Published in:Modern rheumatology 2008-02, Vol.18 (1), p.86-90
Main Authors: Miyake, Katsuhisa, Moriyama, Masafumi, Aizawa, Kumiko, Nagano, Shuji, Inoue, Yasushi, Sadanaga, Atsushi, Nakashima, Hitoshi, Nakamura, Seiji
Format: Article
Language:English
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Summary:Abstract Mikulicz's disease (MD) is a unique IgG4-related systemic disease indicated by enlargement of the lachrymal and salivary glands and which differs substantially from Sjögren's syndrome. A male patient with pleural effusion, swelling of the submandibular glands, and swelling of the paraaortic, mediastinal, and pararenal lymph nodes was diagnosed with MD. Analysis of peripheral CD4+ T cells from the patient revealed deviation of the Th1/Th2 balance to Th2. Prednisolone therapy ameliorated the disease and corrected the Th1/Th2 imbalance.
ISSN:1439-7595
1439-7609
DOI:10.3109/s10165-007-0010-3