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A case of immunoglobulin G4-related chronic sclerosing sialadenitis and dacryoadenitis associated with tuberculosis

Abstract We describe a 64-year-old woman with chronic sclerosing sialadenitis and dacryoadenitis, which developed during treatment for cervical lymph node tuberculosis. Anti-tuberculosis treatment did not improve the swelling in the lacrimal and submandibular glands, and a biopsy specimen of the lac...

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Published in:Modern rheumatology 2009-02, Vol.19 (1), p.87-90
Main Authors: Kawano, Mitsuhiro, Yamada, Kazunori, Kakuchi, Yasushi, Ito, Kiyoaki, Hamano, Ryoko, Fujii, Hiroshi, Inoue, Ryo, Matsumura, Masami, Takahira, Masayuki, Zen, Yoh, Yachie, Akihiro, Nakashima, Akikatsu, Yamagishi, Masakazu
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container_title Modern rheumatology
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creator Kawano, Mitsuhiro
Yamada, Kazunori
Kakuchi, Yasushi
Ito, Kiyoaki
Hamano, Ryoko
Fujii, Hiroshi
Inoue, Ryo
Matsumura, Masami
Takahira, Masayuki
Zen, Yoh
Yachie, Akihiro
Nakashima, Akikatsu
Yamagishi, Masakazu
description Abstract We describe a 64-year-old woman with chronic sclerosing sialadenitis and dacryoadenitis, which developed during treatment for cervical lymph node tuberculosis. Anti-tuberculosis treatment did not improve the swelling in the lacrimal and submandibular glands, and a biopsy specimen of the lacrimal gland showed inflammation, with abundant lymphoid follicles with fibrosis and granuloma without caseous necrosis. Immunohistological examination of a repeat biopsy specimen showed abundant immunoglobulin (Ig) G4-positive plasma cell infiltration. Corticosteroid therapy improved the salivary gland swelling without reactivation of the tuberculosis. This case suggests that an abnormal immunological reaction to tuberculosis may be one of the etiological candidates for IgG4-related disease.
doi_str_mv 10.3109/s10165-008-0127-z
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title A case of immunoglobulin G4-related chronic sclerosing sialadenitis and dacryoadenitis associated with tuberculosis
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