Hyaluronan-binding receptors: possible involvement in osteoarthritis

Abstract Our objectives were to compare the expression of the hyaluronan receptors CD44 and RHAMM in knee synovial tissue of patients with and without advanced osteoarthritis (OA). Both receptors were detected immunohistochemically; the staining appeared more intense in the tissues from the patients...

Full description

Saved in:
Bibliographic Details
Published in:Modern rheumatology 2009-04, Vol.19 (2), p.151-155
Main Authors: Dunn, Sharon, Kolomytkin, Oleg V., Waddell, David D., Marino, Andrew A.
Format: Article
Language:English
Subjects:
CD44
Hyaluronan-binding proteins
Osteoarthritis
RHAMM
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Our objectives were to compare the expression of the hyaluronan receptors CD44 and RHAMM in knee synovial tissue of patients with and without advanced osteoarthritis (OA). Both receptors were detected immunohistochemically; the staining appeared more intense in the tissues from the patients with advanced OA. Expression of CD44 and RHAMM were each significantly increased (p < 0.05) in synovial tissue from patients with OA, as determined by means of Western-blot analysis. The findings suggested that changes in levels of the HA-binding proteins might be implicated in the development or progression of OA.
ISSN:1439-7595
1439-7609
DOI:10.3109/s10165-008-0136-y