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Churg-Strauss syndrome associated with elevated levels of serum interleukin-5 and T cell receptor-Cβ gene rearrangement

Abstract A 58-year-old woman was diagnosed with Churg-Strauss syndrome (CSS) based on the symptoms of bronchial asthma, eosinophilia, mononeuritis multiplex and histological examination of the right sural nerve. Prior to treatment, the serum interleukin (IL)-5 level was high, and rearrangement of th...

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Bibliographic Details
Published in:Modern rheumatology 2011-02, Vol.21 (1), p.76-78
Main Authors: Horai, Yoshiro, Miyamura, Tomoya, Takahama, Soichiro, Hirata, Akie, Nakamura, Masataka, Ando, Hitoshi, Minami, Rumi, Yamamoto, Masahiro, Suematsu, Eiichi
Format: Article
Language:English
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Summary:Abstract A 58-year-old woman was diagnosed with Churg-Strauss syndrome (CSS) based on the symptoms of bronchial asthma, eosinophilia, mononeuritis multiplex and histological examination of the right sural nerve. Prior to treatment, the serum interleukin (IL)-5 level was high, and rearrangement of the T cell receptor (TCR) gene was identified. This is the first report of TCR gene rearrangement in a patient with CSS. The expanded T cell clone may be responsible for the overproduction of IL-5. Further studies are warranted to disclose a prevalence of TCR gene rearrangement in CSS patients and its pathophysiological roles in the development of this disease.
ISSN:1439-7595
1439-7609
DOI:10.3109/s10165-010-0341-3