Anti-tumor activity of squid ink

The anti-tumor activity of a new type of peptidoglycan isolated from squid ink was shown to have a cure rate of 64% for Meth A tumor from BALB/c mice. The ink delipidated in acetone, which con-tained the peptidoglycan at 0.1% (w/w), was administered to tumor-transplanted mice so as to examine the an...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Nutritional Science and Vitaminology 1997, Vol.43(4), pp.455-461
Main Authors: Sasaki, J. (Hirosaki Univ., Aomori (Japan). School of Medicine), Ishita, K, Takaya, Y, Uchisawa, H, Matsue, H
Format: Article
Language:English
Subjects:
Acetone
Acetylgalactosamine - analysis
AGENTES ANTINEOPLASTICOS
Animals
anti-tumor activity
ANTINEOPLASTIC AGENTS
Antineoplastic Agents - therapeutic use
Biological and medical sciences
CALAMAR
CALMAR
Carcinogens
Decapodiformes - metabolism
delipidated fraction
Drug Stability
Fibrosarcoma - chemically induced
Fibrosarcoma - drug therapy
Fucose - analysis
General pharmacology
Glucuronates - analysis
Glucuronic Acid
Hot Temperature
lipid fraction
Lipids
macro-phage activation
MACROFAGOS
MACROPHAGE
MACROPHAGES
Medical sciences
MEDICAMENT CYTOSTATIQUE
Melanins - analysis
Mice
Mice, Inbred BALB C
Neoplasm Transplantation
Peptidoglycan - analysis
Peptidoglycan - isolation & purification
Peptidoglycan - therapeutic use
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Polysaccharides - analysis
squid ink
SQUIDS
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The anti-tumor activity of a new type of peptidoglycan isolated from squid ink was shown to have a cure rate of 64% for Meth A tumor from BALB/c mice. The ink delipidated in acetone, which con-tained the peptidoglycan at 0.1% (w/w), was administered to tumor-transplanted mice so as to examine the anti-tumor activity. One-fifth of the tumor-bearing mice was cured with 3 injections (1 mg/head) of the acetone delipidated squid ink or a prolongation of survival was observed in the treated animals. Heat treatment at 100°C for 10 min did not affect the anti-tumor activity of the delipidated ink, its potentiality being pre-served. The acetone-extractable fraction of the ink also brought about a similar cure rate for Meth A tumor. The delipidated ink enhanced the phagocytic activity of macrophages but no direct cytotoxicity was observed for the Meth A tumor cells. Hence it may be said that the anti-tumor activity of the delipidated ink was mainly due to the aug-mented cellular immunity in vivo.
ISSN:0301-4800
1881-7742
DOI:10.3177/jnsv.43.455