Improvement of Vitamin D Status in Japanese Institutionalized Elderly by Supplementation with 800 IU of Vitamin D3

• Published in: Journal of Nutritional Science and Vitaminology 2009, Vol.55(6), pp.453-458
• Main Authors: KUWABARA, Akiko, TSUGAWA, Naoko, TANAKA, Kiyoshi, FUJII, Minori, KAWAI, Nobuko, MUKAE, Sachiko, KATO, Yuzuru, KOJIMA, Yasuko, TAKAHASHI, Kaori, OMURA, Kazumasa, KAGAWA, Reiko, INOUE, Akira, NOIKE, Toshiaki, KIDO, Shoko, OKANO, Toshio
• Format: Article
• Language: English
• Subjects: adequate intake; Biological and medical sciences; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; hypovitaminosis D; institutionalized elderly; Vertebrates: anatomy and physiology, studies on body, several organs or systems; vitamin D
• ISSN: 0301-4800; 1881-7742
• DOI: 10.3177/jnsv.55.453

To study the adequate intake (AI) for vitamin D in the elderly, we have performed an intervention study with 800 IU/d of vitamin D3 in the institutionalized elderly. Sixty-two institutionalized elderly were randomly assigned to two groups; receiving either supplements of 200 mg calcium plus 800 IU vitamin D3/d (Ca+VD group), or supplements of 200 mg calcium/d (Ca group) for 30 d in October. Serum concentrations of 25-hydroxyvitamin D (25OH-D), parathyroid hormone (PTH), and bone turnover markers were measured before and after intervention. Average dietary vitamin D intake during the intervention period was approximately 300 IU/d in both groups, exceeding the AI in Dietary Reference Intakes for Japanese 2005 of 200 IU/d. In both groups, mean serum 25OH-D level at baseline fell into the hypovitaminosis D range (9.7 ng/mL), despite apparently adequate vitamin D intake. Serum PTH level at baseline was within the reference range. Mean serum 25OH-D concentration significantly increased to 19.3 ng/mL in the Ca+VD group and to 11.1 ng/mL in the Ca group. Post intervention serum 25OH-D level was significantly higher in the Ca+VD group than in the Ca group (p