Inhibition of low-density lipoprotein oxidation by Nagano Purple grape (Vitis vinifera x Vitis labrusca)

The Nagano Purple grape (Vitis (V.) vinifera x V. labrusca) is a hybrid created by a cross between Kyoho (V. vinifera x V. labrusca) and Rosario Bianco (V. vinifera) grapes. The grape, including its skin, can be eaten and contains no seeds because of gibberellin treatment. The skins of various fruit...

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Bibliographic Details
Published in:Journal of Nutritional Science and Vitaminology 2009, Vol.55(6), pp.471-478
Main Authors: Kamiyama, M., Nagano-ken. General Industrial Technology Center (Japan), Kishimoto,Y, Tani, M, Andoh, K, Utsunomiya, K, Kondo, K
Format: Article
Language:English
Subjects:
ANTHOCYANE
anthocyanin
ANTHOCYANINS
antioxidant
ANTIOXIDANTES
ANTIOXIDANTS
ANTIOXYDANT
ANTOCIANINAS
Biological and medical sciences
DESSERT GRAPES
Feeding. Feeding behavior
FLAVONOIDE
FLAVONOIDES
FLAVONOIDS
Fundamental and applied biological sciences. Psychology
grape
GRAPES
http://www.fao.org/aos/agrovoc#c_2215
http://www.fao.org/aos/agrovoc#c_28427
http://www.fao.org/aos/agrovoc#c_2964
http://www.fao.org/aos/agrovoc#c_3359
http://www.fao.org/aos/agrovoc#c_4367
http://www.fao.org/aos/agrovoc#c_511
http://www.fao.org/aos/agrovoc#c_5472
http://www.fao.org/aos/agrovoc#c_6259
http://www.fao.org/aos/agrovoc#c_8840
INHIBICION
INHIBITION
LIPOPROTEINAS
LIPOPROTEINE
LIPOPROTEINS
low-density lipoprotein
OXIDACION
OXIDATION
OXYDATION
PROTEINAS
PROTEINE
PROTEINS
RAISIN
RAISIN DE TABLE
UVA
UVAS DE MESA
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:The Nagano Purple grape (Vitis (V.) vinifera x V. labrusca) is a hybrid created by a cross between Kyoho (V. vinifera x V. labrusca) and Rosario Bianco (V. vinifera) grapes. The grape, including its skin, can be eaten and contains no seeds because of gibberellin treatment. The skins of various fruits have been shown to contain antioxidant activity. However, it is unclear whether the Nagano Purple grape contains antioxidant activity. We prepared the skins and dried fruits (including the skins) of the Nagano Purple grape, so as to assay for the presence of an antioxidant activity. We examined the concentration of polyphenols in the grape and further assayed whether components in the grape inhibited the oxidation of low-density lipoprotein (LDL). We detected the presence of cyanidin-3-glucoside (Cy-3-glc), five anthocyanidins and resveratrol in the skins. A trace of resveratrol was detected in the pulp. LDL collected from human subjects 1 h following the consumption of the skins or dried fruits revealed significant inhibition of LDL oxidation compared to that observed in fasting venous blood samples. We further observed the antioxidant activity of Cy-3-glc. Our results suggest that the consumption of the Nagano Purple grape can give rise to resistance to LDL oxidation.
ISSN:0301-4800
1881-7742
DOI:10.3177/jnsv.55.471