The soy isoflavone equol enhances antigen-specific IgE production in ovalbumin-immunized BALB/c mice

Although an immunomodulatory role of the soy isoflavone genistein has been demonstrated, the effects of other soy isoflavones on induction of antigen (Ag)-specific immune responses are not known. In this study, we therefore investigated the effects of daidzein and equol on ovalbumin (OVA)-specific T...

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Bibliographic Details
Published in:Journal of Nutritional Science and Vitaminology 2010, Vol.56(1), pp.72-76
Main Authors: Sakai, T., Tokushima Univ. (Japan), Furoku, S, Nakamoto, M, Shuto, E, Hosaka, T, Nishioka, Y, Sone, S
Format: Article
Language:English
Subjects:
Biological and medical sciences
equol
FACTEUR IMMUNOLOGIQUE
FACTORES INMUNOLOGICOS
Feeding. Feeding behavior
FLAVONOIDE
FLAVONOIDES
FLAVONOIDS
Fundamental and applied biological sciences. Psychology
GLICOPROTEINAS
GLYCOPROTEINE
GLYCOPROTEINS
http://www.fao.org/aos/agrovoc#c_14477
http://www.fao.org/aos/agrovoc#c_29621
http://www.fao.org/aos/agrovoc#c_2964
http://www.fao.org/aos/agrovoc#c_3307
http://www.fao.org/aos/agrovoc#c_34031
http://www.fao.org/aos/agrovoc#c_3805
http://www.fao.org/aos/agrovoc#c_3914
http://www.fao.org/aos/agrovoc#c_4795
IgE
IL-13
IMMUNOGLOBULINE
IMMUNOGLOBULINS
IMMUNOLOGICAL FACTORS
INMUNOGLOBULINA
INTERFERON
INTERFERONAS
INTERFERONS
INTERLEUKINE
INTERLEUKINS
INTERLEUQUINAS
MICE
RATON
SOJA
SOURIS
soy isoflavone
SOYBEANS
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Although an immunomodulatory role of the soy isoflavone genistein has been demonstrated, the effects of other soy isoflavones on induction of antigen (Ag)-specific immune responses are not known. In this study, we therefore investigated the effects of daidzein and equol on ovalbumin (OVA)-specific T cell and B cell responses in BALB/c mice. Mice that had been treated with 20 mg/kg equol showed a significantly higher level of OVA-specific IgE than control mice. Levels of interferon (IFN)-gamma and interleukin (IL)-4 production were not different between the control and equol groups. However, IL-13 production level in mice administered 20 mg/kg equol was significantly higher than that in control mice. Strong induction of OVA-specific IgE production by equol was also observed in ovariectomized BALB/c mice, suggesting that the immunomodulatory effect of equol is not affected by endogenous estrogen.
ISSN:0301-4800
1881-7742
DOI:10.3177/jnsv.56.72