Lactobacillus plantarum OLL2712 Regulates Glucose Metabolism in C57BL/6 Mice Fed a High-Fat Diet

The aim of the present study was to determine the effect of oral administration of Lactobacillus plantarum OLL2712 (L. plantarum OLL2712) on glucose and lipid metabolism in mice with high-fat diet-induced obesity. Mice that had been administered 109 cfu heat-killed L. plantarum OLL2712 for 12 wk sho...

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Bibliographic Details
Published in:Journal of Nutritional Science and Vitaminology 2013, Vol.59(2), pp.144-147
Main Authors: SAKAI, Tohru, TAKI, Tomoyo, NAKAMOTO, Akiko, SHUTO, Emi, TSUTSUMI, Rie, TOSHIMITSU, Takayuki, MAKINO, Seiya, IKEGAMI, Shuuji
Format: Article
Language:English
Subjects:
adipose tissue
inflammation
Lactobacillus plantarum
obesity
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Summary:The aim of the present study was to determine the effect of oral administration of Lactobacillus plantarum OLL2712 (L. plantarum OLL2712) on glucose and lipid metabolism in mice with high-fat diet-induced obesity. Mice that had been administered 109 cfu heat-killed L. plantarum OLL2712 for 12 wk showed significant reduction of blood glucose levels in response to insulin. Furthermore, mRNA expression of interleukin-1β in adipose tissue and serum levels of nonesterified fatty acids in mice administered L. plantarum OLL2712 were significantly lower than those in control mice. These results indicate that L. plantarum OLL2712 regulates glucose metabolism.
ISSN:0301-4800
1881-7742
DOI:10.3177/jnsv.59.144