Nobiletin Enhances Induction of Antigen-Specific Immune Responses in BALB/c Mice Immunized with Ovalbumin

We examined the effect of nobiletin (5,6,7,8,3′,4′-hexamethoxyflavone) on immune response in ovalbumin (OVA)-immunized mice. Treatment with nobiletin increased OVA-specific IL-4 and IL-10 production. In addition, mice that received nobiletin showed higher levels of OVA-specific IgE, IgG and IgG1 pro...

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Bibliographic Details
Published in:Journal of Nutritional Science and Vitaminology 2019/06/30, Vol.65(3), pp.278-282
Main Authors: NAKAMOTO, Akiko, MITANI, Mami, URAYAMA, Kana, MAKI, Akari, NAKAMOTO, Mariko, SHUTO, Emi, NII, Yoshitaka, SAKAI, Tohru
Format: Article
Language:English
Subjects:
antigen presentation
citrus fruits
dendritic cells
immunization
polymethoxylated flavonoid
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Summary:We examined the effect of nobiletin (5,6,7,8,3′,4′-hexamethoxyflavone) on immune response in ovalbumin (OVA)-immunized mice. Treatment with nobiletin increased OVA-specific IL-4 and IL-10 production. In addition, mice that received nobiletin showed higher levels of OVA-specific IgE, IgG and IgG1 production than did control mice. The antibody response to the thymus-independent antigen 2,4,6-trinitrophenyl-Ficoll was not different in the control and nobiletin groups, suggesting that nobiletin does not directly stimulate antibody production. An in vitro study showed that treatment with nobiletin enhanced the ability of antigen presentation of bone marrow-derived dendritic cells. The in vivo and in vitro results indicate that nobiletin regulates immune function.
ISSN:0301-4800
1881-7742
DOI:10.3177/jnsv.65.278