High-Dose Vitamin C Preadministration Reduces Vancomycin-Associated Nephrotoxicity in Mice

Vancomycin is recommended for treating severe infections caused by Gram-positive cocci, including methicillin-resistant Staphylococcus aureus. However, renal damage often occurs as a side effect because vancomycin is mainly excreted via the kidneys. The mechanism of vancomycin-associated nephrotoxic...

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Published in:Journal of Nutritional Science and Vitaminology 2019/10/31, Vol.65(5), pp.399-404
Main Authors: TAKIGAWA, Masaki, YATSU, Tomofumi, TAKINO, Yuka, MATSUMOTO, Shigekiyo, KITANO, Takaaki, LEE, Jaewon, ARAI, Tomio, TANAKA, Hiroyuki, ISHII, Toshihiro, MORI, Yoshiko, ISHIGAMI, Akihito
Format: Article
Language:English
Subjects:
ascorbic acid
CD10
creatinine
kidney
nephrotoxicity
urine
vancomycin
vitamin C
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Summary:Vancomycin is recommended for treating severe infections caused by Gram-positive cocci, including methicillin-resistant Staphylococcus aureus. However, renal damage often occurs as a side effect because vancomycin is mainly excreted via the kidneys. The mechanism of vancomycin-associated nephrotoxicity is thought to involve the elevation of oxidative stress in the kidneys. Vitamin C (VC) has strong antioxidant properties; therefore, we evaluated the effect of high-dose VC preadministration on vancomycin-associated nephrotoxicity. Vancomycin was intraperitoneally injected into mice once daily for 7 d. Additionally, high-dose VC was intraperitoneally injected into mice at 30 min before vancomycin administration for 7 d. The plasma creatinine and urea nitrogen levels were increased by vancomycin treatment; however, high-dose VC preadministration suppressed the increase in these levels. Histological examination also revealed that high-dose VC preadministration reduced the characteristics of vancomycin-associated nephrotoxicity, such as dilated renal tubules with casts, the dilation of renal proximal tubules, and tubular epithelial desquamation. Furthermore, high-dose VC preadministration reduced the appearance of apoptotic cells presumably derived from the epithelial cells in the dilated proximal tubules. Thus, intraperitoneally injected high-dose VC preadministration reduced vancomycin-associated nephrotoxicity in mice. These novel findings may indicate that vancomycin-associated nephrotoxicity in humans may be reduced by high-dose VC preadministration.
ISSN:0301-4800
1881-7742
DOI:10.3177/jnsv.65.399