Effective Timing of Curcumin Ingestion to Attenuate Eccentric Exercise-Induced Muscle Soreness in Men

• Published in: Journal of Nutritional Science and Vitaminology 2019/02/28, Vol.65(1), pp.82-89
• Main Authors: TANABE, Yoko, CHINO, Kentaro, SAGAYAMA, Hiroyuki, LEE, Hyun Jin, OZAWA, Hitomi, MAEDA, Seiji, TAKAHASHI, Hideyuki
• Format: Article
• Language: English
• Subjects: delayed-onset muscle soreness; eccentric contractions; elbow flexors; maximal voluntary contraction; supplementation
• ISSN: 0301-4800; 1881-7742
• DOI: 10.3177/jnsv.65.82

Curcumin is known to have potent anti-inflammatory effects. We have reported that acute curcumin ingestion attenuates eccentric exercise-induced muscle damage. This study aimed to examine the effect of curcumin ingestion timing (before or after exercise) on the changes in muscle damage markers after eccentric exercise. In this randomized, single-blind, parallel design study, 24 healthy young men performed 30 maximal isokinetic (120º/s) eccentric contractions of the elbow flexors using an isokinetic dynamometer. Subjects were randomly assigned to ingest 180 mg/d of oral curcumin either 7 d before (PRE) or 4 d after exercise (POST) or 180 mg/d of oral placebo 4 d after exercise (CON). The maximal voluntary contraction (MVC) torque of the elbow flexors, elbow joint range of motion (ROM), muscle soreness, and serum creatine kinase (CK) activity were measured before, immediately after, and 1-4 d after exercise. Changes in these variables were compared over time. In the POST group, ROM were higher at 3-4 d and muscle soreness was lower at 3 d after exercise compared with the CON group (p