Maternal Level of 25-Hydroxyvitamin D during Pregnancy Associated with Risk of Type 1 Diabetes in the Offspring, a Meta-Analysis

• Published in: Journal of Nutritional Science and Vitaminology 2020/10/31, Vol.66(5), pp.402-408
• Main Authors: KANG, Xinyi, CUI, Jiawen, ZHANG, Mingjin, WANG, Ying, TANG, Weichun, CHEN, Liping
• Format: Article
• Language: English
• Subjects: association exploration; childhood glycometabolism; factor analysis; gestational trimester; maternal vitamin D level
• ISSN: 0301-4800; 1881-7742
• DOI: 10.3177/jnsv.66.402

This aim of this meta-analysis was to evaluate the association between risk of childhood type 1 diabetes and maternal 25-hydroxyvitamin D [25(OH)D] levels during pregnancy. A literature search on databases including PubMed and Embase was conducted up to December 2018. The pooled odds radio weighted mean difference (WMD) and the corresponding 95% confidence intervals (CIs) were calculated using the RevMan 5.3 software. A total of 4 studies were included in this meta-analysis. The overall analysis indicated that the maternal 25(OH)D levels during pregnancy was significantly associated with the risk of type 1 diabetes in offspring (WMD=−2.54, 95% CI=−4.65 to −0.44, p=0.02). The subgroup analyses showed that sample for detection vitamin D (serum/plasma) may not a factor influencing the results of this meta-analysis. However, gestational trimester may be a factor affecting the results. The results showed that no significant association was observed between risk of type 1 diabetes in offspring and 25(OH)D level during first or second gestational trimester (p>0.05). Lower maternal 25(OH)D levels during pregnancy is associated with higher risk of type 1 diabetes in offspring. Gestational trimester may be a factor influencing the results of this meta-analysis.