ANTIOXIDANT AND CELL PROLIFERATION INDUCTION ACTIVITIES COMBINATION OF HYDROALCOHOL EXTRACT OF Artocarpus lacucha Buch. Ham. LEAVES AND Anredera cordifolia (Ten) Steenis. LEAVES

• Published in: Rasāyan journal of chemistry 2022-04, Vol.15 (2), p.1563-1566
• Main Authors: Nazliniwaty, Hanafiah, O.A, D. Pertiwi, M. Muhammad, D. Satria
• Format: Article
• Language: English
• ISSN: 0974-1496; 0974-1496
• DOI: 10.31788/RJC.2022.1526442

The uncontrolled production of oxygen free radicals and the unbalanced mechanism of antioxidant protection results in the onset of many diseases, such as cancer, diabetes, Alzheimer’s, heart diseases, and aging. Artocarpus lacucha Buch.-Ham. Belongs to the family of Moraceae, popularly regarded as a medicinal plant, and commonly called monkey jack. Anredera cordifolia (Ten.) Steenis also known as Binahong is a family of Basellaceae. Both the plants are widely used in traditional medicine. The aim of this study was to determine the antioxidant activity and proliferation activity of combination ethanol extract of Artocarpus lacucha leaves (EEAL) and Anredera cordifolia leaves (EEAC). The extract was prepared using ethanol 80% with the maceration method. Antioxidant activity was determined with the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. Proliferation activity was determined with an MTT assay. Antioxidant activity from combination with DPPH assay is measured as the percent of scavenging and the best combination is 37.5 µg/mL for EEAL and 12.5 µg/mL for EEAC. Proliferation activity in combination with MTT assay is measured as a percent of viability cells and the best combination is 37.5 µg/mL for EEAL and 37.5 µg/mL for EEAC. The results reveal that combination hydroalcoholic extract of Artocarpus lacucha Buch.-Ham. Leaves and Anredera cordifolia (Ten.) Steenis leaves have antioxidant and proliferative activity