DESIGN, SYNTHESIS, AND MOLECULAR DOCKING STUDY OF NEW ARYLTHIOETHER-AMIDE LINKED SULFONYL PIPERAZINE HYBRIDS AS ANTIBACTERIAL AGENTS

Antibiotic resistance is a significant global health concern, and innovative antimicrobial agents are needed to combat this. A study aimed to synthesize and assess the antibacterial activity of sulfonyl piperazine hybrids linked by arylthioether-amide. Nine derivatives were evaluated against Gram-po...

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Bibliographic Details
Published in:Rasāyan journal of chemistry 2024, Vol.17 (3), p.972-984
Main Authors: Aishwarya, B. N., Chandra, M. Subhosh, Manjunath, D. Meti, Nanjunda Swamy, Shivananju, Katta, Vamsi, A. More, Uttam, Ramakrishna, B., Yadav, P. Suresh, Shubha, Priya Babu
Format: Article
Language:English
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Summary:Antibiotic resistance is a significant global health concern, and innovative antimicrobial agents are needed to combat this. A study aimed to synthesize and assess the antibacterial activity of sulfonyl piperazine hybrids linked by arylthioether-amide. Nine derivatives were evaluated against Gram-positive and Gram-negative bacteria. Compounds 9b, 9e, and 9i showed significant antibacterial effectiveness, surpassing conventional medications. Molecular docking studies revealed strong binding affinities of these compounds to the DNA gyrase A binding pocket, highlighting their potential as antibacterial agents. The findings suggest that further research is warranted to explore the therapeutic potential, safety profile, and mechanistic insights of these compounds, particularly 9b and 9i, which show promise for future development as novel antibacterial agents.
ISSN:0974-1496
0974-1496
DOI:10.31788/RJC.2024.1738841