Efficient α-chlorination of 2-[(1-oxocyclohex-2-en-2-yl)methyl]-1,3-dicarbonyl Compounds Using Sodium Hypochlorite

A rapid and efficient regioselective α-chlorination of a new series of β-dicarbonyl compounds using a commercial solution of sodium hypochlorite in the presence of K 2 CO 3 in THF at 0 °C, is reported. With prolonged reaction times, α-chloro β-keto esters, bearing an acyl moiety, undergo a tandem ch...

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Bibliographic Details
Published in:Journal of chemical research 2013-02, Vol.37 (2), p.122-124
Main Authors: Mhasni, Olfa, Rezgui, Farhat
Format: Article
Language:English
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Summary:A rapid and efficient regioselective α-chlorination of a new series of β-dicarbonyl compounds using a commercial solution of sodium hypochlorite in the presence of K 2 CO 3 in THF at 0 °C, is reported. With prolonged reaction times, α-chloro β-keto esters, bearing an acyl moiety, undergo a tandem chlorination–deacylation reaction, affording the corresponding α-chlorinated esters.
ISSN:1747-5198
2047-6507
DOI:10.3184/174751913X13587668947648