A One-Pot Method for the Synthesis of Phenylalkynyl-Substituted Terminal Alkynes by Deprotection/Stannylation followed by a Migita–Kosugi–Stille coupling

A practical one-pot approach for the synthesis of arylalkynyl-substituted terminal alkynes has been developed through a deprotection/ stannylation of a phenylethynyl phosphine oxide followed by Migita–Kosugi–Stille coupling, avoiding the longer synthetic route involving repeated deprotection/Sonogas...

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Bibliographic Details
Published in:Journal of chemical research 2018-06, Vol.42 (5), p.235-238
Main Authors: Peng, Li-fen, Wang, Bing-hao, Wang, Ming, Tang, Zi-long, Jiang, Yan-zi, Jiao, Yin-chun, Xu, Xin-hua
Format: Article
Language:English
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Summary:A practical one-pot approach for the synthesis of arylalkynyl-substituted terminal alkynes has been developed through a deprotection/ stannylation of a phenylethynyl phosphine oxide followed by Migita–Kosugi–Stille coupling, avoiding the longer synthetic route involving repeated deprotection/Sonogashira coupling. Other features of this approach include mild reaction conditions, excellent yields, facile isolation of products and wide functional group tolerance.
ISSN:1747-5198
2047-6507
DOI:10.3184/174751918X15258743466204