A Review on Alzheimer’s disease and mesenchymal stem cell therapy

Alzheimer's disease (AD) is a progressive neurological ailment that manifests as difficulties in completing everyday activities, disorientation, and memory loss. Several innovative drug therapies have failed in clinical trials because they cannot stop or encourage the regeneration of injured br...

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Bibliographic Details
Published in:Journal of Shifa Tameer-e-Millat University 2022-09, Vol.5 (1), p.54-63
Main Authors: Ullah, Aman, Abbasi, Saad Hanif, Badshah, Ismail, Latif, Komal, Mateen, Abdul, Aslam, Adnan, Rehman, Nafees Ur, Anwar, Mansoor, Bhutta, Ahmed Hussain, Khan, Muhammad Imran
Format: Article
Language:English
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Summary:Alzheimer's disease (AD) is a progressive neurological ailment that manifests as difficulties in completing everyday activities, disorientation, and memory loss. Several innovative drug therapies have failed in clinical trials because they cannot stop or encourage the regeneration of injured brain cells. Furthermore, many medications only give symptomatic alleviation. As a result, a better knowledge of stem cell therapy's process might lead to new and effective treatments for this severe disease. Recent preclinical evidence suggests that stem cells can be used to treat or model AD. The mechanisms of stem cell based therapies for AD include stem cell mediated neuroprotection and trophic actions, antiamyloidogenesis, beneficial immune modulation, and the replacement of the lost neurons. This study examined the present status of many Mesenchymal stem cell-based therapeutics in AD pathogenesis. Furthermore, we have emphasized current clinical research that may be useful in treating Alzheimer's disease. 
ISSN:2617-8095
2617-8109
DOI:10.32593/jstmu/Vol5.Iss1.190