Neonatal lupus erythematous – A report of three cases

Neonatal lupus erythematosus (NLE) is a rare acquired autoimmune disorder clinically characterized by skin lesions that resemble those of subacute or discoid lupus erythematosus and/or congenital heart bock. Skin and cardiac manifestations coexist only in 10% of the patients. It is caused by transpl...

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Bibliographic Details
Published in:Indian journal of child health 2017-12, Vol.4 (4), p.631-634
Main Authors: Chhajed, Punit S, Savaskar, S V, Bhori, N S, Bandichhode, S T
Format: Article
Language:English
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Summary:Neonatal lupus erythematosus (NLE) is a rare acquired autoimmune disorder clinically characterized by skin lesions that resemble those of subacute or discoid lupus erythematosus and/or congenital heart bock. Skin and cardiac manifestations coexist only in 10% of the patients. It is caused by transplacental passage of maternal autoantibodies, usually anti-Ro/SS-A and /or anti-La/SS-B and less commonly anti-U1 ribonucleoprotein. Mothers of the infants with NLE are either asymptomatic or diagnosed with autoimmune disease. We describe 3 neonates with clinical and immunological findings compatible with NLE, their progress and outcome.
ISSN:2349-6118
2349-6126
DOI:10.32677/IJCH.2017.v04.i04.040