Reduction of resistance artery stiffness by treatment with the AT1-receptor antagonist losartan in essential hypertension

In spontaneously hypertensive rats resistance artery structure, endothelial dysfunction and geometry-independent wall stiffness were reduced by an angiotensin AT1-receptor antagonist. In previous studies of human hypertension, interruption of the renin-angiotensin system corrected small artery struc...

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Bibliographic Details
Published in:Journal of the renin-angiotensin-aldosterone system 2000-03, Vol.1 (1), p.40-45
Main Authors: Jeong Bae Park, Intengan, Hope D, Schiffrin, Ernesto L
Format: Article
Language:English
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Summary:In spontaneously hypertensive rats resistance artery structure, endothelial dysfunction and geometry-independent wall stiffness were reduced by an angiotensin AT1-receptor antagonist. In previous studies of human hypertension, interruption of the renin-angiotensin system corrected small artery structure and endothelial dysfunction, whereas the β-blocker atenolol did not. We hypothesized that the AT1R antagonist losartan, but not the β-blocker atenolol, would reduce stiffness of gluteal subcutaneous small arteries in essential hypertensive patients. Seventeen untreated mild essential hypertensive patients (47±2years; 75% male) were randomly assigned in double-blind fashion to losartan or atenolol treatment for one year. Small, resistance size arteries were studied on pressurized myographs. Blood pressure (mmHg) was reduced (p
ISSN:1470-3203
1752-8976
DOI:10.3317/jraas.2000.009