Irritation Test and Melanin Whitening Cream Epigallocatechin Gallate Green Tea Leaf with Mexameter and Self-Assessment

Background: Green tea (Camelia sinensis L.) contains flavonoids consisting of Epigallocatechin gallate (EGCG) which functions as whitening, anti-acne, antioxidant, anti-inflammatory. Previous studies have shown that EGCG with a concentration of 6% is the optimum concentration in cream formulations (...

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Bibliographic Details
Published in:Bangladesh journal of medical science (Ibn Sina Trust) 2024-01, Vol.23 (1), p.102-107
Main Authors: Widyaningrum, Naniek, Fathnin, Fildza Huwaina, Ayu N, Yuyun Darma, Sari, Bella N
Format: Article
Language:English
Online Access:Get full text
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Summary:Background: Green tea (Camelia sinensis L.) contains flavonoids consisting of Epigallocatechin gallate (EGCG) which functions as whitening, anti-acne, antioxidant, anti-inflammatory. Previous studies have shown that EGCG with a concentration of 6% is the optimum concentration in cream formulations (Widyaningrum, 2015b). Phase One Clinical Test was conducted to determine the safety of cream preparations with irritation as a benchmark and continued to test its effectiveness as a whitening cream on 20 respondents aged 17-45 years. Material and Methods: The research method employed was the Open Test. The results of the study for 21 days after applying the EGCG anti-acne cream were assessed using a mexa-meter and self-assessment. Result: The erythema assessment showed that the preparation did not cause irritation in the absence of erythema and for the melanin assessment, the results were not significant with p Value 0.376 (
ISSN:2223-4721
2076-0299
DOI:10.3329/bjms.v23i1.70694